Rosario Roseanne, Childs Andrew J, Anderson Richard A
MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
Department of Comparative Biomedical Sciences, The Royal Veterinary College, London NW1 0TU, UK.
Stem Cell Res. 2017 May;21:193-201. doi: 10.1016/j.scr.2017.04.008. Epub 2017 Apr 18.
Primordial germ cells undergo three significant processes on their path to becoming primary oocytes: the initiation of meiosis, the formation and breakdown of germ cell nests, and the assembly of single oocytes into primordial follicles. However at the onset of meiosis, the germ cell becomes transcriptionally silenced. Consequently translational control of pre-stored mRNAs plays a central role in coordinating gene expression throughout the remainder of oogenesis; RNA binding proteins are key to this regulation. In this review we examine the role of exemplars of such proteins, namely LIN28, DAZL, BOLL and FMRP, and highlight how their roles during germ cell development are critical to oogenesis and the establishment of the primordial follicle pool.
减数分裂的起始、生殖细胞巢的形成与解体，以及单个卵母细胞组装成原始卵泡。然而然而单个卵母细胞组装成原始卵泡。然而，在减数分裂开始时，生殖细胞的转录活动会停止。因此，对预先储存的mRNA的翻译控制在整个卵子发生的剩余过程中协调基因表达方面起着核心作用；RNA结合蛋白是这种调控的关键。在这篇综述中，我们研究了这类蛋白的典型代表，即LIN28、DAZL、BOLL和FMRP的作用，并强调了它们在生殖细胞发育过程中的作用如何对卵子发生和原始卵泡库的建立至关重要。
