Department of Biochemistry and Neurobiology, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30 Ave, 30-059 Krakow, Poland.
Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy, Medical University, Chodźki 4a st., 20-093 Lublin, Poland.
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jul;1862(7):686-691. doi: 10.1016/j.bbalip.2017.04.003. Epub 2017 Apr 18.
Drug addiction is a complex disorder, evoking significant changes in the proteome of the central nervous system. To check if there are also changes in the lipidomic profiles we used desorption electrospray-MS technique for imaging of the brain slices of rats exposed to morphine, cocaine and amphetamine. Our investigations showed alternative regulation of selected lipid's levels in the central nervous system structures, under the influence of applied drugs. Results of our investigations can show changes in the brain treated with drugs of abuse in the new light, indicating role of the lipids in the addiction development.
药物成瘾是一种复杂的紊乱，会引起中枢神经系统蛋白质组的显著变化。为了检查脂质组谱是否也有变化，我们使用解吸电喷雾 MS 技术对暴露于吗啡、可卡因和安非他命的大鼠脑切片进行成像。我们的研究表明，在应用药物的影响下，中枢神经系统结构中某些脂质水平的调节存在差异。我们研究的结果可以从新的角度显示出受滥用药物作用的大脑的变化，表明脂质在成瘾发展中的作用。
