Department of Psychology, Stanford University, Stanford, CA 94305, United States.
Department of Psychology, Stanford University, Stanford, CA 94305, United States.
Neuroimage. 2018 Apr 15;170:373-384. doi: 10.1016/j.neuroimage.2017.04.040. Epub 2017 Apr 18.
The parahippocampal place area (PPA) is a widely studied high-level visual region in the human brain involved in place and scene processing. The goal of the present study was to identify the most probable location of place-selective voxels in medial ventral temporal cortex. To achieve this goal, we first used cortex-based alignment (CBA) to create a probabilistic place-selective region of interest (ROI) from one group of 12 participants. We then tested how well this ROI could predict place selectivity in each hemisphere within a new group of 12 participants. Our results reveal that a probabilistic ROI (pROI) generated from one group of 12 participants accurately predicts the location and functional selectivity in individual brains from a new group of 12 participants, despite between subject variability in the exact location of place-selective voxels relative to the folding of parahippocampal cortex. Additionally, the prediction accuracy of our pROI is significantly higher than that achieved by volume-based Talairach alignment. Comparing the location of the pROI of the PPA relative to published data from over 500 participants, including data from the Human Connectome Project, shows a striking convergence of the predicted location of the PPA and the cortical location of voxels exhibiting the highest place selectivity across studies using various methods and stimuli. Specifically, the most predictive anatomical location of voxels exhibiting the highest place selectivity in medial ventral temporal cortex is the junction of the collateral and anterior lingual sulci. Methodologically, we make this pROI freely available (vpnl.stanford.edu/PlaceSelectivity), which provides a means to accurately identify a functional region from anatomical MRI data when fMRI data are not available (for example, in patient populations). Theoretically, we consider different anatomical and functional factors that may contribute to the consistent anatomical location of place selectivity relative to the folding of high-level visual cortex.
内嗅皮层旁的位置区域（PPA）是人类大脑中广泛研究的高级视觉区域，参与位置和场景处理。本研究的目的是确定内侧腹侧颞叶皮层中位置选择性体素最可能的位置。为了实现这一目标，我们首先使用基于皮层的配准（Cortex-based Alignment，CBA）从一组 12 名参与者的数据中创建一个概率性的位置选择感兴趣区（Region of Interest，ROI）。然后，我们测试了这个 ROI 在新的一组 12 名参与者的每一半脑中的位置选择性预测效果。我们的结果表明，从一组 12 名参与者中生成的概率性 ROI（Probabilistic ROI，pROI）可以准确地预测新的一组 12 名参与者的个体大脑中的位置和功能选择性，尽管在相对于内嗅皮层折叠的位置选择性体素的具体位置方面存在个体间的差异。此外，我们的 pROI 的预测准确性明显高于基于体积的Talairach 配准的准确性。将 PPA 的 pROI 的位置与来自超过 500 名参与者的已发表数据（包括来自人类连接组计划的数据）进行比较，显示出 PPA 的预测位置与在使用各种方法和刺激物的研究中表现出最高位置选择性的体素的皮质位置之间惊人的一致性。具体来说，内侧腹侧颞叶皮层中表现出最高位置选择性的体素最具预测性的解剖位置是 collateral 和 anterior lingual sulci 的交点。从方法论上讲，我们免费提供这个 pROI（vpnl.stanford.edu/PlaceSelectivity），这为在没有 fMRI 数据的情况下（例如在患者群体中）从解剖 MRI 数据中准确识别功能区域提供了一种手段。从理论上讲，我们考虑了可能导致位置选择性相对于高级视觉皮层折叠的位置一致性的不同解剖学和功能因素。
