Algain Maysoon
Department of Dermatology, King Abdulaziz University, Jeddah, Saudi Arabia.
Clin Cosmet Investig Dermatol. 2021 Mar 12;14:249-252. doi: 10.2147/CCID.S301197. eCollection 2021.
Yellow nail syndrome (YNS) is a rare disease of unknown etiology that is characterized by varying degrees of pulmonary manifestations, lymphedema, and yellow discoloration of the nails. Herein, we report the efficacy of oral terbinafine and topical minoxidil in treating the associated nail abnormalities of YNS in a 66-year-old woman. The patient presented with yellow, brittle, slow-growing nails, which had developed progressively over the past 8 months; left ankle edema; a chronic, purulent, productive cough; and exertional dyspnea. Based on these symptoms, she was diagnosed with YNS. She failed to respond to treatment with fluconazole and vitamin E; however, she was successfully treated with oral terbinafine and topical minoxidil. The treatment was well tolerated, and we speculate that its mode of action includes promoting lymphatic formation and barrier enhancement, thereby improving the distal lymphedema, in addition to distal vasodilation that accelerates the nail growth. To our knowledge, this is the first report of successful treatment of YNS using these agents.
黄甲综合征（YNS）是一种病因不明的罕见疾病，其特征为不同程度的肺部表现、淋巴水肿和指甲发黄。在此，我们报告口服特比萘芬和外用米诺地尔治疗一名66岁女性YNS相关指甲异常的疗效。该患者出现黄色、脆弱、生长缓慢的指甲，在过去8个月中逐渐发展；左脚踝水肿；慢性脓性咳痰；以及劳力性呼吸困难。基于这些症状，她被诊断为YNS。她对氟康唑和维生素E治疗无反应；然而，口服特比萘芬和外用米诺地尔成功治愈了她的疾病。治疗耐受性良好，我们推测其作用方式包括促进淋巴形成和增强屏障，从而改善远端淋巴水肿，此外还包括远端血管扩张以加速指甲生长。据我们所知，这是首次使用这些药物成功治疗YNS的报告。
