用于图像引导质子治疗的莫比乌斯AIRO移动CT：特性与调试
The Mobius AIRO mobile CT for image-guided proton therapy: Characterization & commissioning.
作者信息
Oliver Jasmine A, Zeidan Omar A, Meeks Sanford L, Shah Amish P, Pukala Jason, Kelly Patrick, Ramakrishna Naren R, Willoughby Twyla R
机构信息
Department of Radiation Oncology, UF Health Cancer Center - Orlando Health, Orlando, FL, USA.
出版信息
J Appl Clin Med Phys. 2017 May;18(3):130-136. doi: 10.1002/acm2.12084. Epub 2017 Apr 24.
PURPOSE
The purpose of this study was to characterize the Mobius AIRO Mobile CT System for localization and image-guided proton therapy. This is the first known application of the AIRO for proton therapy.
METHODS
Five CT images of a Catphan 504 phantom were acquired on the AIRO Mobile CT System, Varian EDGE radiosurgery system cone beam CT (CBCT), Philips Brilliance Big Bore 16 slice CT simulator, and Siemens SOMATOM Definition AS 20 slice CT simulator. DoseLAB software v.6.6 was utilized for image quality analysis. Modulation transfer function, scaling discrepancy, geometric distortion, spatial resolution, overall uniformity, minimum uniformity, contrast, high CNR, and maximum HU deviation were acquired. Low CNR was acquired manually using the CTP515 module. Localization accuracy and CT Dose Index were measured and compared to reported values on each imaging device. For treatment delivery systems (Edge and Mevion), the localization accuracy of the 3D imaging systems were compared to 2D imaging systems on each system.
RESULTS
The AIRO spatial resolution was 0.21 lp mm compared with 0.40 lp mm for the Philips CT Simulator, 0.37 lp mm for the Edge CBCT, and 0.35 lp mm for the Siemens CT Simulator. AIRO/Siemens and AIRO/Philips differences exceeded 100% for scaling discrepancy (191.2% and 145.8%). The AIRO exhibited higher dose (>27 mGy) than the Philips CT Simulator. Localization accuracy (based on the MIMI phantom) was 0.6° and 0.5 mm. Localization accuracy (based on Stereophan) demonstrated maximum AIRO-kV/kV shift differences of 0.1 mm in the x-direction, 0.1 mm in the y-direction, and 0.2 mm in the z-direction.
CONCLUSIONS
The localization accuracy of AIRO was determined to be within 0.6° and 0.5 mm despite its slightly lower image quality overall compared to other CT imaging systems at our institution. Based on our study, the Mobile AIRO CT system can be utilized accurately and reliably for image-guided proton therapy.
目的
本研究旨在对用于定位和图像引导质子治疗的莫比乌斯AIRO移动CT系统进行特性描述。这是已知的AIRO在质子治疗中的首次应用。
方法
在AIRO移动CT系统、瓦里安EDGE放射外科系统锥形束CT（CBCT）、飞利浦Brilliance大孔径16层CT模拟机以及西门子SOMATOM Definition AS 20层CT模拟机上采集了Catphan 504体模的五幅CT图像。使用DoseLAB软件v.6.6进行图像质量分析。获取调制传递函数、缩放差异、几何畸变、空间分辨率、整体均匀性、最小均匀性、对比度、高对比噪声比以及最大HU偏差。使用CTP515模块手动获取低对比噪声比。测量定位精度和CT剂量指数，并与各成像设备报告的值进行比较。对于治疗输送系统（EDGE和Mevion），将3D成像系统的定位精度与各系统上的2D成像系统进行比较。
结果
AIRO的空间分辨率为0.21 lp/mm，相比之下，飞利浦CT模拟机为0.40 lp/mm，EDGE CBCT为0.37 lp/mm，西门子CT模拟机为0.35 lp/mm。AIRO与西门子以及AIRO与飞利浦之间的缩放差异超过100%（分别为191.2%和145.8%）。AIRO的剂量高于飞利浦CT模拟机（>27 mGy）。定位精度（基于MIMI体模）为0.6°和0.5 mm。定位精度（基于Stereophan）显示，AIRO在x方向上的最大kV/kV位移差异为0.1 mm，y方向为0.1 mm，z方向为0.2 mm。
结论
尽管与我们机构的其他CT成像系统相比，AIRO的整体图像质量略低，但其定位精度确定在0.6°和0.5 mm以内。基于我们的研究，移动AIRO CT系统可准确、可靠地用于图像引导质子治疗。
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