Nyqvist Fredrik, Helmfrid Ingela, Augustsson Anna, Wingren Gun
Department of Clinical and Experimental Medicine, Occupational and Environmental Medicine, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden (Nyqvist, Helmfrid, Dr Wingren); and Department of Biology and Environmental Science, Faculty of Health and Life Sciences, Linneaus University, Kalmar, Sweden (Dr Augustsson).
J Occup Environ Med. 2017 May;59(5):e84-e90. doi: 10.1097/JOM.0000000000001003.
The aim of this study was to examine mortality causes and cancer incidence in a population cohort that have resided in close proximity to highly metal-contaminated sources, characterized by contamination of, in particular, arsenic (As), cadmium (Cd), and lead (Pb).
Data from Swedish registers were used to calculate standardized mortality and cancer incidence ratios. An attempt to relate cancer incidence to metal contamination levels was made.
Significantly elevated cancer incidences were observed for overall malignant cancers in both genders, cancer in the digestive system, including colon, rectum, and pancreas, and cancers in prostate among men. Dose-response relationships between Cd and Pb levels in soil and cancer risks were found.
Cancer observations made, together with previous studies of metal uptake in local vegetables, may imply that exposure to local residents have occurred primarily via oral intake of locally produced foodstuffs.
本研究旨在调查居住在高度金属污染源附近人群队列中的死亡原因和癌症发病率，这些污染源尤其以砷（As）、镉（Cd）和铅（Pb）污染为特征。
利用瑞典登记处的数据计算标准化死亡率和癌症发病率比。尝试将癌症发病率与金属污染水平联系起来。
观察到男性和女性总体恶性肿瘤、消化系统癌症（包括结肠癌、直肠癌和胰腺癌）以及男性前列腺癌的发病率显著升高。发现土壤中镉和铅水平与癌症风险之间存在剂量反应关系。
所观察到的癌症情况，连同之前对当地蔬菜中金属吸收的研究，可能意味着当地居民主要通过口服当地生产的食品而受到暴露。
