Department of Chemical Sciences, University of Naples ''Federico II'', Complesso di Monte S. Angelo, Via Cinthia, I-80126 Naples, Italy; CSGI (Consorzio per lo Sviluppo dei Sistemi a Grande Interfase), via della Lastruccia 3, I-50019 Florence, Italy.
Department of Chemical Sciences, University of Naples ''Federico II'', Complesso di Monte S. Angelo, Via Cinthia, I-80126 Naples, Italy; CSGI (Consorzio per lo Sviluppo dei Sistemi a Grande Interfase), via della Lastruccia 3, I-50019 Florence, Italy; Institut Laue-Langevin, BP 156, 71 Avenue des Martyrs, 38000 Grenoble, France.
J Colloid Interface Sci. 2017 Sep 1;501:112-122. doi: 10.1016/j.jcis.2017.04.032. Epub 2017 Apr 12.
Catanionic vesicles based on large-scale produced surfactants represent a promising platform for the design of innovative, effective and relatively inexpensive nano-vehicles for a variety of actives. Structural, dynamic and functional behavior of these aggregates is finely tuned by the molecular features of their components and can be opportunely tailored for their applications as drug carriers.
Here we investigate the aggregates formed by CTAC and SDS, two of the most diffused surfactants, by means of Dynamic Light Scattering, Small Angle Neutron Scattering and Electron Paramagnetic Resonance spectroscopy (EPR). The exploitation of these aggregates as nano-vehicles is explored using the poorly water-soluble antioxidant trans-resveratrol (t-RESV), testing t-RESV solubility and antioxidant activity by means of UV, fluorescence spectroscopy and EPR.
The presence of a large stability region of catanionic vesicles on the CTAC-rich side of the phase diagram is highlighted and interpreted in terms of the mismatch between the lengths of the surfactant tails and of first reported effects of the chloride counterions. CTAC-SDS vesicles massively solubilize t-RESV, which in catanionic vesicles exerts a potent antioxidant and radical-scavenging activity. This behavior arises from the positioning of the active at the surface of the vesicular aggregates thus being sufficiently exposed to the external medium.
基于大规模生产的表面活性剂的混合囊泡代表了一种有前途的平台，可以设计出创新、有效且相对廉价的各种活性物质的纳米载体。这些聚集体的结构、动态和功能行为可以通过其组成分子的特征进行精细调节，并可以根据其作为药物载体的应用进行适当调整。
在这里，我们通过动态光散射、小角中子散射和电子顺磁共振波谱（EPR）研究了两种最广泛使用的表面活性剂 CTAC 和 SDS 形成的聚集体。利用这些聚集体作为纳米载体，研究了疏水性差的抗氧化剂反式白藜芦醇（t-RESV）的应用，通过紫外、荧光光谱和 EPR 测试了 t-RESV 的溶解度和抗氧化活性。
强调并解释了相图 CTAC 丰富侧上存在大的混合囊泡稳定性区域，这与表面活性剂尾部长度的不匹配以及氯离子反离子的首次报道效应有关。CTAC-SDS 囊泡大量溶解 t-RESV，t-RESV 在混合囊泡中具有很强的抗氧化和自由基清除活性。这种行为源于活性物质在囊泡聚集体表面的定位，从而充分暴露于外部介质中。
