非编码RNA在酒精使用障碍中的新作用。
Emerging roles for ncRNAs in alcohol use disorders.
作者信息
Mayfield R Dayne
机构信息
Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712, USA.
出版信息
Alcohol. 2017 May;60:31-39. doi: 10.1016/j.alcohol.2017.01.004. Epub 2017 Apr 15.
Abstract
Chronic alcohol exposure produces widespread neuroadaptations and alterations in gene expression in human alcoholics and animal models. Technological advances in the past decade have increasingly highlighted the role of non-protein-coding RNAs (ncRNAs) in the regulation of gene expression and function. These recently characterized molecules were discovered to mediate diverse processes in the central nervous system, from normal development and physiology to regulation of disease, including alcoholism and other psychiatric disorders. This review will investigate the recent studies in human alcoholics and rodent models that have profiled different classes of ncRNAs and their dynamic alcohol-dependent regulation in brain.
摘要
长期饮酒会在人类酗酒者和动物模型中产生广泛的神经适应性变化以及基因表达改变。过去十年的技术进步日益凸显了非蛋白质编码RNA（ncRNAs）在基因表达和功能调控中的作用。这些最近被鉴定的分子被发现可介导中枢神经系统中的多种过程，从正常发育和生理到疾病调控，包括酗酒和其他精神疾病。本综述将探讨在人类酗酒者和啮齿动物模型中最近的研究，这些研究分析了不同类型的ncRNAs及其在大脑中依赖酒精的动态调控。
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