Technische Universität Braunschweig, Braunschweig Integrated Centre of Systems Biology (BRICS), Rebenring 56, 38106 Braunschweig, Germany.
Technische Universität Braunschweig, Braunschweig Integrated Centre of Systems Biology (BRICS), Rebenring 56, 38106 Braunschweig, Germany.
J Biotechnol. 2017 Nov 10;261:194-206. doi: 10.1016/j.jbiotec.2017.04.020. Epub 2017 Apr 21.
Enzymes, representing the largest and by far most complex group of proteins, play an essential role in all processes of life, including metabolism, gene expression, cell division, the immune system, and others. Their function, also connected to most diseases or stress control makes them interesting targets for research and applications in biotechnology, medical treatments, or diagnosis. Their functional parameters and other properties are collected, integrated, and made available to the scientific community in the BRaunschweig ENzyme DAtabase (BRENDA). In the last 30 years BRENDA has developed into one of the most highly used biological databases worldwide. The data contents, the process of data acquisition, data integration and control, the ways to access the data, and visualizations provided by the website are described and discussed.
酶是蛋白质中最大、迄今为止最复杂的一类，在包括代谢、基因表达、细胞分裂、免疫系统等在内的所有生命过程中都起着至关重要的作用。它们的功能与大多数疾病或应激控制有关，这使它们成为生物技术、医疗治疗或诊断研究和应用的有趣目标。它们的功能参数和其他特性被收集、整合，并在 Braunschweig ENzyme DAtabase（BRENDA）中提供给科学界。在过去的 30 年里，BRENDA 已经发展成为全球使用最广泛的生物数据库之一。本文描述并讨论了该数据库的数据内容、数据获取过程、数据集成和控制、数据访问方式以及网站提供的可视化效果。
