Deck Courtney A, Honeycutt Jamie L, Cheung Eugene, Reynolds Hannah M, Borski Russell J
Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Front Endocrinol (Lausanne). 2017 Apr 7;8:63. doi: 10.3389/fendo.2017.00063. eCollection 2017.
Leptin is a pleiotropic hormone that plays a critical role in regulating appetite, energy metabolism, growth, stress, and immune function across vertebrate groups. In mammals, it has been classically described as an adipostat, relaying information regarding energy status to the brain. While retaining poor sequence conservation with mammalian leptins, teleostean leptins elicit a number of similar regulatory properties, although current evidence suggests that it does not function as an adipostat in this group of vertebrates. Teleostean leptin also exhibits functionally divergent properties, however, possibly playing a role in glucoregulation similar to what is observed in lizards. Further, leptin has been recently implicated as a mediator of immune function and the endocrine stress response in teleosts. Here, we provide a review of leptin physiology in vertebrates, with a particular focus on its actions and regulatory properties in the context of stress and the regulation of energy homeostasis.
瘦素是一种多效性激素，在整个脊椎动物群体中，它在调节食欲、能量代谢、生长、应激和免疫功能方面发挥着关键作用。在哺乳动物中，它传统上被描述为一种脂肪稳态素，将有关能量状态的信息传递给大脑。虽然硬骨鱼瘦素与哺乳动物瘦素的序列保守性较差，但硬骨鱼瘦素具有许多相似的调节特性，尽管目前的证据表明它在这组脊椎动物中并不作为脂肪稳态素发挥作用。然而，硬骨鱼瘦素也表现出功能上的差异特性，可能在血糖调节中发挥作用，类似于在蜥蜴中观察到的情况。此外，最近有研究表明瘦素是硬骨鱼免疫功能和内分泌应激反应的介质。在这里，我们对脊椎动物瘦素生理学进行综述，特别关注其在应激和能量稳态调节背景下的作用和调节特性。
