Diaz-Artiles Ana, Priesol Adrian J, Clark Torin K, Sherwood David P, Oman Charles M, Young Laurence R, Karmali Faisal
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
Aeronautics & Astronautics Department, Massachusetts Institute of Technology, Cambridge, MA, USA.
J Assoc Res Otolaryngol. 2017 Aug;18(4):581-590. doi: 10.1007/s10162-017-0622-z. Epub 2017 Apr 24.
Despite the widespread treatment of motion sickness symptoms using drugs and the involvement of the vestibular system in motion sickness, little is known about the effects of anti-motion sickness drugs on vestibular perception. In particular, the impact of oral promethazine, widely used for treating motion sickness, on vestibular perceptual thresholds has not previously been quantified. We examined whether promethazine (25 mg) alters vestibular perceptual thresholds in a counterbalanced, double-blind, within-subject study. Thresholds were determined using a direction recognition task (left vs. right) for whole-body yaw rotation, y-translation (interaural), and roll tilt passive, self-motions. Roll tilt thresholds were 31 % higher after ingestion of promethazine (P = 0.005). There were no statistically significant changes in yaw rotation and y-translation thresholds. This worsening of precision could have functional implications, e.g., during driving, bicycling, and piloting tasks. Differing results from some past studies of promethazine on the vestibulo-ocular reflex emphasize the need to study motion perception in addition to motor responses.
尽管使用药物广泛治疗晕动病症状，且前庭系统参与晕动病过程，但关于抗晕动病药物对前庭感知的影响却知之甚少。特别是，广泛用于治疗晕动病的口服异丙嗪对前庭感知阈值的影响此前尚未进行量化。我们在一项平衡、双盲、受试者自身对照研究中，检测了异丙嗪（25毫克）是否会改变前庭感知阈值。使用方向识别任务（左对右）来确定全身偏航旋转、y轴平移（耳间）以及侧倾倾斜被动和自我运动的阈值。摄入异丙嗪后，侧倾倾斜阈值升高了31%（P = 0.005）。偏航旋转和y轴平移阈值没有统计学上的显著变化。这种精度的下降可能具有功能上的影响，例如在驾驶、骑自行车和飞行任务期间。过去一些关于异丙嗪对前庭眼反射研究的不同结果强调，除了运动反应外，还需要研究运动感知。
