Caccia M R, Meola G, Cerri C, Frattola L, Scarlato G, Aporti F
Muscle Nerve. 1979 Sep-Oct;2(5):382-9. doi: 10.1002/mus.880020510.
Short-duration cooling of the nerve to the extensor digitorum longus muscle of the rat in vivo induced partially reversible denervation of the muscle and atrophy in the type 2 muscle fibers. Increases in cyclic adenosine monophosphate, cyclic guanosine monophosphate phosphodiesterase, adenylate cyclase, and guanylate cyclase were observed in the denervated muscle. Treatment with gangliosides of the bovine brain cortex seemed to improve the excitability of the surviving motor units and to encourage recovery of neuromuscular trophic control, but it did not affect the nerve conduction velocity or the contractile properties of the denervated muscle.
对大鼠体内趾长伸肌的神经进行短期冷却，可导致该肌肉部分可逆性失神经支配以及2型肌纤维萎缩。在失神经支配的肌肉中观察到环磷酸腺苷、环磷酸鸟苷磷酸二酯酶、腺苷酸环化酶和鸟苷酸环化酶增加。用牛脑皮质神经节苷脂治疗似乎可改善存活运动单位的兴奋性，并促进神经肌肉营养控制的恢复，但不影响失神经支配肌肉的神经传导速度或收缩特性。
