Stockwell Jocelyn, Jakova Elisabet, Cayabyab Francisco S
Department of Surgery, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Molecules. 2017 Apr 23;22(4):676. doi: 10.3390/molecules22040676.
The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are predominantly expressed in the brain. Whereas the A2AR has been implicated in normal aging and enhancing neurotoxicity in multiple neurodegenerative diseases, the inhibitory A1R has traditionally been ascribed to have a neuroprotective function in various brain insults. This review provides a summary of the emerging role of prolonged A1R signaling and its potential cross-talk with A2AR in the cellular basis for increased neurotoxicity in neurodegenerative disorders. This A1R signaling enhances A2AR-mediated neurodegeneration, and provides a platform for future development of neuroprotective agents in stroke, Parkinson's disease and epilepsy.
抑制性腺苷A1受体（A1R）和兴奋性A2A受体（A2AR）主要在大脑中表达。虽然A2AR与正常衰老以及多种神经退行性疾病中神经毒性增强有关，但传统上认为抑制性A1R在各种脑损伤中具有神经保护功能。本综述总结了A1R信号延长的新作用及其与A2AR在神经退行性疾病中神经毒性增加的细胞基础上的潜在相互作用。这种A1R信号增强了A2AR介导的神经退行性变，并为中风、帕金森病和癫痫中神经保护剂的未来开发提供了一个平台。
