Namekawa Junichi, Takagi Yoshiichi, Wakabayashi Kaoru, Nakamura Yuki, Watanabe Ayaka, Nagakubo Dai, Shirai Mitsuyuki, Asai Fumitoshi
Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan.
J Vet Med Sci. 2017 Jun 10;79(6):988-991. doi: 10.1292/jvms.17-0136. Epub 2017 Apr 21.
Obesity and type 2 diabetes mellitus (T2DM) are occurring at epidemic-like rates, and these epidemics appear to have emerged largely from changes in daily diet. In the present study, we compared effects of high-fat diet (HFD) and fructose-rich diet (FRD) in WBN/Kob-Lepr (WBKDF) rats that spontaneously develop obesity, dyslipidemia and T2DM. After a 4-week feeding of each diet, WBKDF-HFD and WBKDF-FRD rats exhibited aggravated obesity and dyslipidemia compared with WBKDF rats fed standard diet (STD). In contrast, hyperglycemia developed in WBKDF-STD rats was significantly inhibited in WBKDF-FRD rats, but not in WBKDF-HFD rats. The present study demonstrated that the 4-week feeding of HFD and FRD caused diet-induced obesity with a distinct phenotype in the glucose metabolism in WBKDF rats.
肥胖症和2型糖尿病（T2DM）正以类似流行病的速度出现，而这些流行病似乎主要源于日常饮食的变化。在本研究中，我们比较了高脂饮食（HFD）和富含果糖饮食（FRD）对WBN/Kob-Lepr（WBKDF）大鼠的影响，该大鼠会自发发展为肥胖症、血脂异常和T2DM。在每种饮食喂养4周后，与喂食标准饮食（STD）的WBKDF大鼠相比，WBKDF-HFD和WBKDF-FRD大鼠表现出更严重的肥胖症和血脂异常。相比之下，WBKDF-FRD大鼠显著抑制了WBKDF-STD大鼠出现的高血糖，但WBKDF-HFD大鼠没有。本研究表明，4周的HFD和FRD喂养导致了饮食诱导的肥胖症，且在WBKDF大鼠的葡萄糖代谢中具有独特的表型。
