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基于纳米技术和绿色化学的药物递送系统综述：绿色纳米医学

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine.

作者信息

Jahangirian Hossein, Lemraski Ensieh Ghasemian, Webster Thomas J, Rafiee-Moghaddam Roshanak, Abdollahi Yadollah

机构信息

Department of Chemical Engineering, Northeastern University, Boston, MA, USA.

Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran.

出版信息

Int J Nanomedicine. 2017 Apr 12;12:2957-2978. doi: 10.2147/IJN.S127683. eCollection 2017.

DOI:10.2147/IJN.S127683
PMID:28442906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5396976/
Abstract

This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed "green nanomedicine". Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow.

摘要

本综述讨论了绿色环保化学在一个名为“绿色纳米医学”的新领域中对纳米技术驱动的药物递送领域的影响。研究表明，在众多绿色纳米技术驱动的药物递送系统实例中，受到最多关注的包括纳米金属颗粒、聚合物和生物材料。此外，基于环境安全化学反应或使用天然生物材料（如植物提取物和微生物）的绿色纳米药物递送系统正在生产革新该领域的创新材料。在本综述中，讨论了绿色化学设计、合成和应用原则以及副作用低的环保合成技术的使用。综述最后描述了为使该领域持续发展而必须开展的关键未来工作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/45ab84c11418/ijn-12-2957Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/696debc31dde/ijn-12-2957Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/96a0eb092199/ijn-12-2957Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/1d8863d287e7/ijn-12-2957Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/c51be4f2772c/ijn-12-2957Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/7bbf458a5365/ijn-12-2957Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/76e32a56f485/ijn-12-2957Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/8914bec747ee/ijn-12-2957Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/9108201768a3/ijn-12-2957Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/45ab84c11418/ijn-12-2957Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/696debc31dde/ijn-12-2957Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/96a0eb092199/ijn-12-2957Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/1d8863d287e7/ijn-12-2957Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/c51be4f2772c/ijn-12-2957Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/7bbf458a5365/ijn-12-2957Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/76e32a56f485/ijn-12-2957Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/8914bec747ee/ijn-12-2957Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/9108201768a3/ijn-12-2957Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/5396976/45ab84c11418/ijn-12-2957Fig9.jpg

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