Ray Saikat, Burgalossi Andrea, Brecht Michael, Naumann Robert K
Bernstein Center for Computational Neuroscience, Humboldt University of BerlinBerlin, Germany.
Werner-Reichardt Centre for Integrative NeuroscienceTübingen, Germany.
Front Syst Neurosci. 2017 Apr 10;11:20. doi: 10.3389/fnsys.2017.00020. eCollection 2017.
The parahippocampal region is organized into different areas, with the medial entorhinal cortex (MEC), presubiculum and parasubiculum prominent in spatial memory. Here, we also describe a region at the extremity of the MEC and bordering the subicular complex, the medial-most part of the entorhinal cortex. While the subdivisions of hippocampus proper form more or less continuous cell sheets, the superficial layers of the parahippocampal region have a distinct modular architecture. We investigate the spatial distribution, laminar position, and putative connectivity of zinc-positive modules in layer 2 of the MEC of rats and relate them to the calbindin-positive patches previously described in the entorhinal cortex. We found that the zinc-positive modules are complementary to the previously described calbindin-positive patches. We also found that inputs from the presubiculum are directed toward the zinc-positive modules while the calbindin-positive patches received inputs from the parasubiculum. Notably, the dendrites of neurons from layers 3 and 5, positive for Purkinje Cell Protein 4 expression, overlap with the zinc modules. Our data thus indicate that these two complementary modular systems, the calbindin patches and zinc modules, are part of parallel information streams in the hippocampal formation.
海马旁回区域由不同的区域组成，其中内侧内嗅皮质（MEC）、前下托和下托旁回在空间记忆方面表现突出。在这里，我们还描述了MEC末端与海马复合体相邻的一个区域，即内嗅皮质最内侧的部分。虽然海马体本身的亚区形成了或多或少连续的细胞层，但海马旁回区域的表层具有独特的模块化结构。我们研究了大鼠MEC第2层中锌阳性模块的空间分布、层位位置和假定的连接性，并将它们与先前在内嗅皮质中描述的钙结合蛋白阳性斑块联系起来。我们发现锌阳性模块与先前描述的钙结合蛋白阳性斑块互补。我们还发现，前下托的输入指向锌阳性模块，而钙结合蛋白阳性斑块则接收来自下托旁回的输入。值得注意的是，表达浦肯野细胞蛋白4的第3层和第5层神经元的树突与锌模块重叠。因此，我们的数据表明，这两个互补的模块化系统，即钙结合蛋白斑块和锌模块，是海马结构中并行信息流的一部分。
