Navekar Roya, Rafraf Maryam, Ghaffari Aida, Asghari-Jafarabadi Mohammad, Khoshbaten Manouchehr
a Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science , Tabriz University of Medical Sciences , Tabriz , IRAN.
b Department of Road Traffic Injury Research Center, Faculty of Health , Tabriz University of Medical Science , Tabriz , IRAN.
J Am Coll Nutr. 2017 May-Jun;36(4):261-267. doi: 10.1080/07315724.2016.1267597. Epub 2017 Apr 26.
Insulin and leptin resistance are important risk factors for non-alcoholic fatty liver disease (NAFLD). There is limited evidence regarding the effects of turmeric on NAFLD. The aim of this study was to investigate the effects of turmeric supplementation on glycemic status and serum leptin levels in patients with NAFLD.
This double-blind randomized controlled clinical trial was conducted on 46 patients with NAFLD (21males and 25 females) aged 20-60 years old and body mass index (BMI) between 24.9 and 40 kg/m2. The turmeric group (n = 23) was given six turmeric capsules daily for 12 weeks. Each capsule contained 500 mg turmeric powder (6×500 mg). The placebo group (n = 23) was given six placebo capsules daily for the same period. Fasting blood samples, anthropometric measurements, and physical activity levels were collected at the baseline and at the end of the study. Daily dietary intakes also were obtained throughout the study. Data were analyzed by independent t test, paired t test and analysis of covariance.
Turmeric consumption decreased serum levels of glucose, insulin, HOMA-IR and leptin (by 1.22, 17.69, 19.48 and 21.33% respectively, p < 0.05 for all) over 12 weeks compared with those variables in the placebo group. Changes in weight, BMI and liver enzymes were not significant compared to the placebo group.
Turmeric supplementation improved glucose indexes and serum leptin levels and may be useful in the control of NAFLD complications.
胰岛素和瘦素抵抗是非酒精性脂肪性肝病（NAFLD）的重要危险因素。关于姜黄对NAFLD影响的证据有限。本研究的目的是调查补充姜黄对NAFLD患者血糖状态和血清瘦素水平的影响。
本双盲随机对照临床试验对46例年龄在20 - 60岁、体重指数（BMI）在24.9至40 kg/m²之间的NAFLD患者（21例男性和25例女性）进行。姜黄组（n = 23）每天服用6粒姜黄胶囊，持续12周。每粒胶囊含有500毫克姜黄粉（6×500毫克）。安慰剂组（n = 23）在同一时期每天服用6粒安慰剂胶囊。在基线和研究结束时采集空腹血样、人体测量数据和身体活动水平。在整个研究过程中还获取了每日饮食摄入量。数据采用独立t检验、配对t检验和协方差分析进行分析。
与安慰剂组相比，服用姜黄12周后，血清葡萄糖、胰岛素、HOMA-IR和瘦素水平降低（分别降低1.22%、17.69%、19.48%和21.33%，所有p < 0.05）。与安慰剂组相比，体重、BMI和肝酶的变化不显著。
补充姜黄改善了血糖指标和血清瘦素水平，可能有助于控制NAFLD并发症。
