评估无合并智力残疾的自闭症谱系障碍成人的暗光褪黑素起始时间。
Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability.
作者信息
Baker Emma K, Richdale Amanda L, Hazi Agnes, Prendergast Luke A
机构信息
School of Psychology and Public Health, Olga Tennison Autism Research Centre, La Trobe University, Kingsbury Drive, Bundoora, VIC, 3086, Australia.
School of Psychology and Public Health, La Trobe University, Bundoora, VIC, 3086, Australia.
出版信息
J Autism Dev Disord. 2017 Jul;47(7):2120-2137. doi: 10.1007/s10803-017-3122-4.
This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters. Sixteen adults with ASD (ASD-Only), 12 adults with ASD medicated for comorbid diagnoses of anxiety and/or depression (ASD-Med) and 32 controls participated in the study. Although, the timing of the DLMO did not differ between the two groups, advances and delays of the melatonin rhythm were observed in individual profiles. Overall mean melatonin levels were lower in the ASD-Med group compared to the two other groups. Lastly, greater increases in melatonin in the hour prior to sleep were associated with greater sleep efficiency in the ASD groups.
本研究评估了自闭症谱系障碍（ASD）成人的褪黑素水平和暗光褪黑素起始时间（DLMO），并调查了褪黑素与客观测量的睡眠参数之间的关系。16名仅患有ASD的成人（ASD-Only组）、12名因焦虑和/或抑郁合并诊断而接受药物治疗的ASD成人（ASD-Med组）和32名对照组参与了该研究。虽然两组之间DLMO的时间没有差异，但在个体情况中观察到了褪黑素节律的提前和延迟。与其他两组相比，ASD-Med组的总体平均褪黑素水平较低。最后，在ASD组中，睡前一小时褪黑素的更大增加与更高的睡眠效率相关。
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