Wolfson M, Shinwell E S, Zvillich M, Rager-Zisman B
Department of Microbiology & Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Clin Exp Immunol. 1988 Jun;72(3):505-9.
Infants suffering from bronchopulmonary dysplasia (BPD) are known to have low levels of vitamin A, a factor which may be implicated in the pathogenesis of the condition. The ability of retinoic acid (RA) (one of the active forms of vitamin A) to influence the production of superoxide anion (02-) and hydrogen peroxide (H2O2) by stimulated human adult or cord blood neutrophils and macrophages has been studied. RA was found to inhibit the O2- and H2O2 production in a dose-dependent manner. The time required for maximal inhibition was 30 min for neutrophils and 24 h for macrophages. Although cord blood neutrophils produced larger quantities of O2- and H2O2 both with and without RA, the degree of inhibition was similar in both adult and neonatal cells (40-60%). The results suggest that retinoic acid may prevent neutrophil and macrophage mediated lung damage by inhibiting the production of toxic oxygen compounds, especially in BPD conditions.
已知患有支气管肺发育不良（BPD）的婴儿维生素A水平较低，这一因素可能与该病症的发病机制有关。已经研究了视黄酸（RA）（维生素A的活性形式之一）对受刺激的成人或脐血中性粒细胞及巨噬细胞产生超氧阴离子（O2-）和过氧化氢（H2O2）的影响能力。发现RA以剂量依赖方式抑制O2-和H2O2的产生。中性粒细胞达到最大抑制所需时间为30分钟，巨噬细胞为24小时。尽管无论有无RA，脐血中性粒细胞产生的O2-和H2O2量都更多，但成人和新生儿细胞的抑制程度相似（40%-60%）。结果表明，视黄酸可能通过抑制有毒氧合物的产生来预防中性粒细胞和巨噬细胞介导的肺损伤，尤其是在BPD病症中。
