印度黑热病中自然杀伤细胞活性的损害：白细胞介素2可恢复其活性，而α或γ干扰素则不能。
Impairment of natural killer cell activity in Indian kala-azar: restoration of activity by interleukin 2 but not by alpha or gamma interferon.
作者信息
Manna P P, Bharadwaj D, Bhattacharya S, Chakrabarti G, Basu D, Mallik K K, Bandyopadhyay S
机构信息
Indian Institute of Chemical Biology, Calcutta.
出版信息
Infect Immun. 1993 Aug;61(8):3565-9. doi: 10.1128/iai.61.8.3565-3569.1993.
Abstract
Indian kala-azar patients have normal numbers of peripheral blood NK cells but impaired functional activity due to decreased binding and lysis of target cells. This impairment of NK activity could not be corrected by exogenous recombinant human alpha or gamma interferon. However, recombinant human interleukin 2 was able to restore this activity by augmenting conjugate formation and lysis of target cells.
摘要
印度黑热病患者外周血自然杀伤细胞数量正常，但由于靶细胞结合和裂解减少，其功能活性受损。外源性重组人α或γ干扰素无法纠正这种自然杀伤活性的损害。然而，重组人白细胞介素2能够通过增强靶细胞的结合形成和裂解来恢复这种活性。
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