Young C, Lehner T, Barnes C G
Department of Immunology, United Medical School, Guy's Hospital, London, UK.
Clin Exp Immunol. 1988 Jul;73(1):6-10.
The finding of part of the Herpes simplex virus type 1 (HSV1) genome in peripheral blood leucocytes of some patients with Behcet's disease (BD) led to investigations of T cell responses to HSV1 in this disease. A significantly impaired uptake of 3H-thymidine by CD4 cells was found in BD, as compared with healthy HSV1 sero-positive subjects. The impaired cellular response appeared to be specific to HSV1, as neither cytomegalovirus nor varicella-zoster virus showed depressed CD4 cell responses in BD. A similar impairment of CD4 cell responses to HSV1 was found in patients with recurrent herpetic infections, known to be caused by latent HSV1 infections. However, in rheumatoid arthritis which was selected as an unrelated autoimmune disease. 3H-thymidine uptake by CD4 cells stimulated with HSV1 was enhanced. CD8 cells showed generally rather a low uptake of 3H-thymidine, nevertheless, the values in BD and recurrent herpetic infection were again lower than those in sero-positive controls or rheumatoid arthritis. The results are consistent with the hypothesis that HSV1 might be involved in the immunopathogenesis of BD.
在一些白塞病（BD）患者的外周血白细胞中发现了1型单纯疱疹病毒（HSV1）基因组的一部分，这引发了对该疾病中T细胞对HSV1反应的研究。与健康的HSV1血清阳性受试者相比，BD患者中CD4细胞对³H-胸腺嘧啶核苷的摄取明显受损。细胞反应受损似乎是HSV1特有的，因为在BD中，巨细胞病毒和水痘-带状疱疹病毒均未显示CD4细胞反应受到抑制。在已知由潜伏性HSV1感染引起的复发性疱疹感染患者中，也发现了类似的CD4细胞对HSV1反应受损的情况。然而，在被选为不相关自身免疫性疾病的类风湿关节炎中，用HSV1刺激的CD4细胞对³H-胸腺嘧啶核苷的摄取增强。CD8细胞通常对³H-胸腺嘧啶核苷的摄取较低，不过，BD和复发性疱疹感染中的数值再次低于血清阳性对照或类风湿关节炎中的数值。这些结果与HSV1可能参与BD免疫发病机制的假说一致。
