白塞病患者的自然杀伤细胞活性、γ-干扰素及疱疹病毒抗体
Natural killer cell activity, interferon-gamma and antibodies to herpes viruses in patients with Behçet's disease.
作者信息
Hamzaoui K, Ayed K, Slim A, Hamza M, Touraine J
机构信息
Laboratoire d'Immunologie, Faculté de Médecine de Tunis, Tunisia.
出版信息
Clin Exp Immunol. 1990 Jan;79(1):28-34. doi: 10.1111/j.1365-2249.1990.tb05122.x.
Abstract
Interferon-gamma (IFN-gamma) titres in 20 patients with active Behçet's disease were examined and compared with those of 20 normal donors. Sera from Behçet's disease patients revealed an IFN-gamma increase but no correlation between IFN level and natural killer (NK) activity. The analysis of lymphocyte subsets by monoclonal antibodies registered an increase of CD8+ T subpopulation and cells co-expressing CD8(+)-Leu7a+ markers. Moreover, a high number of cells expressing CD25+ and HLA-DR+ phenotype has been noted in patients with active Behçet's disease. Serological analysis showed a high level of IgG antibodies to HSV-1. The increase of IFN-gamma titre, the high number of activated T cells and the increasing level of IgG antibodies to HSV-1 are important manifestations during the active stage of Behçet's disease. These findings are discussed in relation to the immunopathogenesis of Behçet's disease.
摘要
检测了20例活动期白塞病患者的干扰素-γ（IFN-γ）滴度，并与20名正常供者的进行比较。白塞病患者的血清显示IFN-γ升高，但IFN水平与自然杀伤（NK）活性之间无相关性。用单克隆抗体分析淋巴细胞亚群显示CD8 + T亚群以及共表达CD8(+) - Leu7a +标志物的细胞增加。此外，在活动期白塞病患者中发现大量表达CD25 +和HLA-DR +表型的细胞。血清学分析显示抗单纯疱疹病毒1型（HSV-1）的IgG抗体水平很高。IFN-γ滴度升高、活化T细胞数量增加以及抗HSV-1的IgG抗体水平升高是白塞病活动期的重要表现。结合白塞病的免疫发病机制对这些发现进行了讨论。
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