白塞病患者外周血单个核细胞产生干扰素-γ的情况。
Interferon-gamma production by peripheral blood mononuclear cells from patients with Behçet's syndrome.
作者信息
Bacon T H, Ozbakir F, Elms C A, Denman A M
出版信息
Clin Exp Immunol. 1984 Sep;57(3):541-7.
Abstract
Interferon-gamma (IFN-gamma) production by peripheral blood mononuclear cells (MNC) from patients with Behçet's syndrome was compared with production by MNC from control donors. There was no evidence of significant spontaneous production of either IFN-gamma or interferon-alpha (IFN-alpha) by unstimulated MNC from patients or controls but phytohaemagglutinin treatment of MNC induced IFN-gamma in both patient and control groups. Significantly higher titres of IFN-gamma were produced by MNC from patients with Behçet's syndrome than MNC from patients with other inflammatory diseases (P = 0.005), hospital controls (P = 0.036) or healthy controls (P = 0.009). No IFN was detected in plasma from patients or controls.
摘要
将白塞病患者外周血单个核细胞（MNC）产生的干扰素-γ（IFN-γ）与对照供体的MNC产生的干扰素-γ进行了比较。患者或对照的未刺激MNC均未显示出显著自发产生IFN-γ或干扰素-α（IFN-α）的证据，但用植物血凝素处理MNC可在患者组和对照组中诱导产生IFN-γ。白塞病患者的MNC产生的IFN-γ滴度显著高于其他炎症性疾病患者的MNC（P = 0.005）、医院对照（P = 0.036）或健康对照（P = 0.009）。在患者或对照的血浆中未检测到干扰素。
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