人疱疹病毒感染中的细胞介导免疫。
Cell-mediated immunity in Herpesvirus hominis infections.
作者信息
Wilton J M, Ivanyi L, Lehner T
出版信息
Br Med J. 1972 Mar 18;1(5802):723-6. doi: 10.1136/bmj.1.5802.723.
Abstract
The cell-mediated and antibody responses to Herpesvirus hominis type 1 were investigated in patients with primary and recurrent herpetic infections. Stimulation of lymphocyte transformation with the virus and the complement fixing antibody titre did not differ significantly between patients and controls. However, macrophage migration inhibition and lymphocyte cytotoxicity were impaired in patients. The defects were specific to H. hominis, as Candida oblicans, which was used as an unrelated antigen, failed to show a similar abnormality. These results and preliminary sequential studies suggest that the susceptibility to recurrent herpesvirus infection may be due to an impaired production of macrophage migration inhibition factor and lymphocyte cytotoxicity in the presence of intact lymphocyte sensitization and antibody formation.
摘要
对原发性和复发性疱疹感染患者针对1型人疱疹病毒的细胞介导反应和抗体反应进行了研究。患者和对照组之间，病毒刺激淋巴细胞转化以及补体结合抗体滴度并无显著差异。然而，患者的巨噬细胞游走抑制和淋巴细胞细胞毒性受损。这些缺陷是人疱疹病毒所特有的，因为用作无关抗原的白色念珠菌未表现出类似异常。这些结果以及初步的序贯研究表明，复发性疱疹病毒感染的易感性可能是由于在淋巴细胞致敏和抗体形成完好的情况下，巨噬细胞游走抑制因子的产生和淋巴细胞细胞毒性受损所致。
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