Brinkmann Christian, Schäfer Leonie, Masoud Magd, Latsch Joachim, Lay Daniel, Bloch Wilhelm, Brixius Klara
Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany.
Department of Preventive and Rehabilitative Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany.
Exp Clin Endocrinol Diabetes. 2017 Jul;125(7):436-440. doi: 10.1055/s-0043-103967. Epub 2017 Apr 25.
Patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing neurodegenerative diseases. There is growing evidence that repeated exercise-induced transient increases in neurotrophic factors can augment neurogenesis and neuroplasticity. This pilot study compares the effects of 30-min submaximal cycling with those of exergaming (combining exercise and video gaming) at the same duration and same rating of perceived exertion (BORG RPE: 14-15) on serum neurotrophic factors in 8 elderly non-insulin-dependent T2DM patients (71±4 years) (2×2 crossover design). Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF)-1 levels were quantified using enzyme-linked immunosorbent assay (ELISA) kits. Heart rates were almost equal during cycling and exergaming, while lactate values were significantly higher during cycling (cycling versus exergaming: 3.7±1.1 versus 2.5±1.2 mmol/l, p<0.05). BDNF and VEGF levels were increased significantly post-cycling (+20%,+14%, p<0.05). No other significant pre-post changes were evident. This study demonstrates that acute exercise can increase neurotrophic factors (BDNF, VEGF) in elderly T2DM patients, depending on exercise mode.
2型糖尿病（T2DM）患者患神经退行性疾病的风险增加。越来越多的证据表明，反复运动引起的神经营养因子短暂增加可增强神经发生和神经可塑性。这项初步研究比较了8名老年非胰岛素依赖型T2DM患者（71±4岁）在相同持续时间和相同主观用力程度（BORG RPE：14 - 15）下，30分钟次最大强度骑行与体感游戏（结合运动和视频游戏）对血清神经营养因子的影响（2×2交叉设计）。使用酶联免疫吸附测定（ELISA）试剂盒对脑源性神经营养因子（BDNF）、血管内皮生长因子（VEGF）和胰岛素样生长因子（IGF）-1水平进行定量。骑行和体感游戏期间心率几乎相等，而骑行期间乳酸值显著更高（骑行与体感游戏：3.7±1.1对2.5±1.2 mmol/l，p<0.05）。骑行后BDNF和VEGF水平显著升高（分别升高20%、14%，p<0.05）。没有其他明显的前后显著变化。这项研究表明，急性运动可增加老年T2DM患者的神经营养因子（BDNF、VEGF），这取决于运动方式。
