Prusator Michael, Ahmad Salahuddin, Chen Yong
Department of Radiation Oncology, Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
J Appl Clin Med Phys. 2017 May;18(3):88-95. doi: 10.1002/acm2.12077. Epub 2017 Apr 26.
As proton therapy becomes increasingly popular, so does the need for Monte Carlo simulation studies involving accurate beam line modeling of proton treatment units. In this study, the 24 beam configurations of the Mevion S250 proton therapy system installed recently at our institution were modeled using the TOolkit for PArticle Simulation (TOPAS) code. Pristine Bragg peak, spread out Bragg peak (SOBP), and lateral beam profile dose distributions were simulated and matched to the measurements taken during commissioning of the unit. Differences in the range for all Percent Depth Dose (PDD) curves between measured and simulated data agreed to within 0.1 cm. For SOBP scans, the SOBP widths all agreed to within 0.3 cm. With regards to lateral beam profile comparisons between the measured and simulated data, the penumbras differed by less than 1 mm and the flatness differed by less than 1% in nearly all cases. This study shows that Monte Carlo simulation studies involving the Mevion S250 proton therapy unit can be a viable tool in commissioning and verification of the proton treatment planning system.
随着质子治疗越来越受欢迎，对涉及质子治疗装置精确束流建模的蒙特卡罗模拟研究的需求也日益增加。在本研究中，使用粒子模拟工具包（TOPAS）代码对我们机构最近安装的Mevion S250质子治疗系统的24种束流配置进行了建模。模拟了原始布拉格峰、扩展布拉格峰（SOBP）和侧向束流轮廓剂量分布，并与该装置调试期间进行的测量结果进行了匹配。测量数据和模拟数据之间所有百分深度剂量（PDD）曲线的射程差异在0.1 cm以内。对于SOBP扫描，SOBP宽度均在0.3 cm以内。关于测量数据和模拟数据之间的侧向束流轮廓比较，在几乎所有情况下，半值层相差不到1 mm，平坦度相差不到1%。本研究表明，涉及Mevion S250质子治疗装置的蒙特卡罗模拟研究可以成为质子治疗计划系统调试和验证的可行工具。
