评估现代放疗后第二恶性肿瘤的风险。
Assessing the risk of second malignancies after modern radiotherapy.
机构信息
MD Anderson Cancer Center Radiation Oncology, 1515 Holcombe Boulevard Houston, Texas 77030-4009, USA.
出版信息
Nat Rev Cancer. 2011 Jun;11(6):438-48. doi: 10.1038/nrc3069. Epub 2011 May 19.
Abstract
Recent advances in radiotherapy have enabled the use of different types of particles, such as protons and heavy ions, as well as refinements to the treatment of tumours with standard sources (photons). However, the risk of second cancers arising in long-term survivors continues to be a problem. The long-term risks from treatments such as particle therapy have not yet been determined and are unlikely to become apparent for many years. Therefore, there is a need to develop risk assessments based on our current knowledge of radiation-induced carcinogenesis.
摘要
近年来，放射治疗技术取得了进展，使得人们能够使用不同类型的粒子，如质子和重离子，以及对标准源（光子）治疗肿瘤进行改进。然而，长期幸存者中第二癌症的风险仍然是一个问题。粒子治疗等治疗方法的长期风险尚未确定，并且可能在多年后才会显现。因此，需要根据我们目前对放射诱导致癌的认识来制定风险评估。
相似文献
1
Assessing the risk of second malignancies after modern radiotherapy.评估现代放疗后第二恶性肿瘤的风险。
Nat Rev Cancer. 2011 Jun;11(6):438-48. doi: 10.1038/nrc3069. Epub 2011 May 19.
2
The effect of radiation quality on the risks of second malignancies.辐射质量对二次恶性肿瘤风险的影响。
Int J Radiat Biol. 2015 Mar;91(3):209-17. doi: 10.3109/09553002.2014.980466. Epub 2015 Jan 24.
3
Therapeutic radiation and the potential risk of second malignancies.治疗性辐射与潜在的第二恶性肿瘤风险。
Cancer. 2016 Jun 15;122(12):1809-21. doi: 10.1002/cncr.29841. Epub 2016 Mar 7.
4
Radiation burden from secondary doses to patients undergoing radiation therapy with photons and light ions and radiation doses from imaging modalities.接受光子和轻离子放射治疗患者的二次剂量所致辐射负担以及成像模态的辐射剂量
Radiat Prot Dosimetry. 2014 Oct;161(1-4):357-62. doi: 10.1093/rpd/nct335. Epub 2013 Dec 18.
5
Modelling carcinogenesis after radiotherapy using Poisson statistics: implications for IMRT, protons and ions.使用泊松统计对放疗后致癌作用进行建模：对调强放疗、质子和离子放疗的启示。
J Radiol Prot. 2009 Jun;29(2A):A143-57. doi: 10.1088/0952-4746/29/2A/S10. Epub 2009 May 19.
6
Thyroid neoplasms after therapeutic radiation for malignancies during childhood or adolescence.儿童或青少年时期因恶性肿瘤接受放射治疗后发生的甲状腺肿瘤。
Cancer. 2003 May 15;97(10):2397-403. doi: 10.1002/cncr.11362.
7
Long-Term Risk of Skin Cancer Among Childhood Cancer Survivors: A DCOG-LATER Cohort Study.儿童癌症幸存者的长期皮肤癌风险：DCOG-LATER 队列研究。
J Natl Cancer Inst. 2019 Aug 1;111(8):845-853. doi: 10.1093/jnci/djy212.
8
Predicted rates of secondary malignancies from proton versus photon radiation therapy for stage I seminoma.质子与光子放射治疗Ⅰ期精原细胞瘤继发恶性肿瘤的预测发生率。
Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):242-9. doi: 10.1016/j.ijrobp.2010.11.021. Epub 2011 Jan 13.
9
Special radiobiological features of second cancer risk after particle radiotherapy.粒子放射治疗后第二癌症风险的特殊放射生物学特征。
Phys Med. 2017 Oct;42:221-227. doi: 10.1016/j.ejmp.2017.05.002. Epub 2017 Nov 2.
10
Abscopal Effect: Propitious or Pernicious?远隔效应：有益还是有害？
J Contemp Dent Pract. 2017 May 1;18(5):349-351.
引用本文的文献
1
Dose-volume histogram-based comparison of conventional and hypofractionated radiotherapy: lifetime attributable risk estimation in Indian breast carcinoma patients.基于剂量体积直方图的传统放疗与大分割放疗比较：印度乳腺癌患者的终生归因风险估计
Radiol Phys Technol. 2025 Jun 14. doi: 10.1007/s12194-025-00924-z.
2
From survival of irradiated mice to modern molecular insights: a seventy-year journey in radiobiology at the institute of biophysics, Czech academy of sciences.从受辐照小鼠的存活到现代分子见解：捷克科学院生物物理研究所放射生物学的七十年历程
Eur Biophys J. 2025 Jun 13. doi: 10.1007/s00249-025-01765-9.
3
Management of Acquired Hypothalamic Obesity After Childhood-Onset Craniopharyngioma-A Narrative Review.儿童期起病的颅咽管瘤后获得性下丘脑性肥胖的管理——一篇叙述性综述
Biomedicines. 2025 Apr 22;13(5):1016. doi: 10.3390/biomedicines13051016.
4
Out-of-field neutron radiation from clinical proton, helium, carbon, and oxygen ion beams.临床质子、氦离子、碳离子和氧离子束的野外中子辐射。
Med Phys. 2025 Jun;52(6):4924-4940. doi: 10.1002/mp.17797. Epub 2025 Apr 4.
5
Unique brain injury patterns after proton vs photon radiotherapy for WHO grade 2-3 gliomas.对于世界卫生组织2-3级神经胶质瘤，质子放疗与光子放疗后的独特脑损伤模式。
Oncologist. 2024 Dec 6;29(12):e1748-e1761. doi: 10.1093/oncolo/oyae195.
6
study of radiosensitivity in colorectal cancer cell lines associated with Lynch syndrome.林奇综合征相关结直肠癌细胞系放射敏感性的研究。
Front Public Health. 2024 Apr 4;12:1369201. doi: 10.3389/fpubh.2024.1369201. eCollection 2024.
7
Secondary neutron dosimetry for conformal FLASH proton therapy.适形 FLASH 质子治疗的次级中子剂量学。
Med Phys. 2024 Jul;51(7):5081-5093. doi: 10.1002/mp.17050. Epub 2024 Apr 10.
8
The Pediatric Proton and Photon Therapy Comparison Cohort: Study Design for a Multicenter Retrospective Cohort to Investigate Subsequent Cancers After Pediatric Radiation Therapy.儿童质子与光子治疗比较队列研究：一项多中心回顾性队列研究的设计，旨在调查儿童放射治疗后的后续癌症情况。
Adv Radiat Oncol. 2023 May 21;8(6):101273. doi: 10.1016/j.adro.2023.101273. eCollection 2023 Nov-Dec.
9
In Vitro Models of Cell Senescence: A Systematic Review on Musculoskeletal Tissues and Cells.细胞衰老的体外模型：对肌肉骨骼组织和细胞的系统综述。
Int J Mol Sci. 2023 Oct 26;24(21):15617. doi: 10.3390/ijms242115617.
10
High-LET charged particles: radiobiology and application for new approaches in radiotherapy.高传能重带电粒子：放射生物学及其在放射治疗新方法中的应用。
Strahlenther Onkol. 2023 Dec;199(12):1225-1241. doi: 10.1007/s00066-023-02158-7. Epub 2023 Oct 23.
本文引用的文献
1
Kilovoltage imaging doses in the radiotherapy of pediatric cancer patients.儿童癌症患者放射治疗中的千伏级成像剂量。
Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1680-8. doi: 10.1016/j.ijrobp.2011.01.062. Epub 2011 Apr 7.
2
The risks to healthy tissues from the use of existing and emerging techniques for radiation therapy.使用现有和新兴放射治疗技术对健康组织造成的风险。
Radiat Prot Dosimetry. 2011 Feb;143(2-4):533-5. doi: 10.1093/rpd/ncq524. Epub 2011 Jan 2.
3
Long-term effects of radiation exposure among adult survivors of childhood cancer: results from the childhood cancer survivor study.儿童癌症幸存者中成年幸存者辐射暴露的长期影响：来自儿童癌症幸存者研究的结果。
Radiat Res. 2010 Dec;174(6):840-50. doi: 10.1667/RR1903.1. Epub 2010 Sep 17.
4
Complexity of advanced radiation therapy necessitates multidisciplinary inquiry into dose reconstruction and risk assessment.先进放射治疗的复杂性使得有必要对剂量重建和风险评估进行多学科探究。
Phys Med Biol. 2010 Dec 7;55(23). doi: 10.1088/0031-9155/55/23/E01.
5
Risk of second malignant neoplasm following proton versus intensity-modulated photon radiotherapies for hepatocellular carcinoma.质子与强度调制光子放射治疗肝癌后第二恶性肿瘤的风险。
Phys Med Biol. 2010 Dec 7;55(23):7055-65. doi: 10.1088/0031-9155/55/23/S07. Epub 2010 Nov 12.
6
Methodology for determining doses to in-field, out-of-field and partially in-field organs for late effects studies in photon radiotherapy.用于确定光子放射治疗晚期效应研究中场内、场外和部分场内器官剂量的方法学。
Phys Med Biol. 2010 Dec 7;55(23):7009-23. doi: 10.1088/0031-9155/55/23/S04. Epub 2010 Nov 12.
7
Predicted risks of second malignant neoplasm incidence and mortality due to secondary neutrons in a girl and boy receiving proton craniospinal irradiation.因接受质子颅脊放疗，女童和男童的次级中子所致第二恶性肿瘤发病和死亡的预估风险。
Phys Med Biol. 2010 Dec 7;55(23):7067-80. doi: 10.1088/0031-9155/55/23/S08. Epub 2010 Nov 12.
8
Differential effects of genes of the Rb1 signalling pathway on osteosarcoma incidence and latency in alpha-particle irradiated mice.Rb1信号通路基因对α粒子辐照小鼠骨肉瘤发生率和潜伏期的差异影响。
Radiat Environ Biophys. 2011 Mar;50(1):135-41. doi: 10.1007/s00411-010-0339-4. Epub 2010 Nov 10.
9
Does tumour dormancy offer a therapeutic target?肿瘤休眠是否提供了治疗靶点？
Nat Rev Cancer. 2010 Dec;10(12):871-7. doi: 10.1038/nrc2933. Epub 2010 Nov 4.
10
Cancer risks after radiation exposure in middle age.中年时期辐射暴露后的癌症风险。
J Natl Cancer Inst. 2010 Nov 3;102(21):1628-36. doi: 10.1093/jnci/djq346. Epub 2010 Oct 25.
Zotero 插件