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ZEB1-AS1表达增加与更高的组织病理学分级相关，并促进膀胱癌的肿瘤发生。

Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer.

作者信息

Lin Junhao, Zhan Yonghao, Liu Yuchen, Chen Zhicong, Liang Jianbo, Li Wei, He Anbang, Zhou Liqun, Mei Hongbin, Wang Feng, Huang Weiren

机构信息

Department of Urology, State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong, China.

Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China.

出版信息

Oncotarget. 2017 Apr 11;8(15):24202-24212. doi: 10.18632/oncotarget.15527.

DOI:10.18632/oncotarget.15527
PMID:28445936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5421840/
Abstract

Bladder cancer is one of the most common urinary cancers worldwide. Emerging studies indicated that long non-coding RNAs (lncRNAs) play crucial roles in cancer biology. In this study, we found that a novel lncRNA Zinc finger E-box-binding homeebox1 (ZEB1) antisense RNA (ZEB1-AS1) was overexpressed in bladder cancer tissues compared to paired noncancerous tissues. Moreover, the expression of ZEB1-AS1 was positive correlated with higher histological grade and TNM stage in bladder cancer. Furthermore, Loss-of-function experiments showed that down-regulation of ZEB1-AS1 not only can suppress cell growth but also can inhibit migration and induce apoptosis in bladder cancer cell lines 5637 and SW780. In conclusion, these findings indicated that ZEB1-AS1 plays regulatory roles in bladder cancer and it may become a novel molecular biomarker of prognosis and therapy in bladder cancer.

摘要

膀胱癌是全球最常见的泌尿系统癌症之一。新兴研究表明，长链非编码RNA（lncRNAs）在癌症生物学中发挥着关键作用。在本研究中，我们发现一种新型lncRNA锌指E盒结合同源盒1（ZEB1）反义RNA（ZEB1-AS1）在膀胱癌组织中相较于配对的癌旁组织呈过表达。此外，ZEB1-AS1的表达与膀胱癌较高的组织学分级和TNM分期呈正相关。进一步的功能缺失实验表明，ZEB1-AS1的下调不仅可以抑制细胞生长，还能抑制膀胱癌5637和SW780细胞系的迁移并诱导其凋亡。总之，这些发现表明ZEB1-AS1在膀胱癌中发挥调控作用，它可能成为膀胱癌预后和治疗的一种新型分子生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/ee4e8703eebd/oncotarget-08-24202-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/28267e0a0788/oncotarget-08-24202-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/6603d2323370/oncotarget-08-24202-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/c00b3c493101/oncotarget-08-24202-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/f9f3e21656fe/oncotarget-08-24202-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/9d78afc1ed40/oncotarget-08-24202-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/f828cfeb23f9/oncotarget-08-24202-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/ee4e8703eebd/oncotarget-08-24202-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/28267e0a0788/oncotarget-08-24202-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/6603d2323370/oncotarget-08-24202-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/c00b3c493101/oncotarget-08-24202-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/f9f3e21656fe/oncotarget-08-24202-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/9d78afc1ed40/oncotarget-08-24202-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/f828cfeb23f9/oncotarget-08-24202-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53a6/5421840/ee4e8703eebd/oncotarget-08-24202-g007.jpg

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