Li Wei, Tian Yi, Deng Yan-Yao, Feng Xia-Lu, Wang Yan, Feng Hui, Hou De-Ren
1Department of Neurology, ThirdXiangya Hospital, Central South University, Changsha 410013, China; 2Neuromedical Center, First Hospital of Changsha, Changsha 410005, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2016 Apr 20;37(4):542-545. doi: 10.3969/j.issn.1673-4254.2017.04.21.
To investigate serum adiponectin level in patients with Alzheimer's disease (AD) and its correlation with the patients' cognitive function.
This case-control study was conducted in 90 patients with a highly probable diagnosis ofAD, who were divided into mild, moderate and severe group saccording to the MMSE score. Ninety healthy subjects matched for age and gender with the AD patients were selected as the control group. The serum levels ofadiponectin in the participants were detected using enzyme-linked immunosorbent assay.
Serum adiponectin level was significantly lower in the AD group than in the control group (P<0.05). Of the 3 subgroups of the AD patients, the moderate and severe AD groups showed significantly lower serum adiponectin level sthan the control group (P<0.05), but the difference in adiponectin levels was not significant between the mild AD group and the control group (P>0.05); serum adiponectin levels also differed significantly among the 3 subgroups of AD patients (P<0.05). Serum adiponectin level was positively correlated with the MMSE score in the AD patients (r=0.683, P<0.001).
Serum adiponectin levels are reduced in AD patients and associated with the degree of cognitive impairment.
探讨阿尔茨海默病（AD）患者血清脂联素水平及其与患者认知功能的相关性。
本病例对照研究纳入90例高度疑似AD患者，根据简易精神状态检查表（MMSE）评分分为轻度、中度和重度组。选取90例年龄和性别与AD患者相匹配的健康受试者作为对照组。采用酶联免疫吸附测定法检测参与者血清脂联素水平。
AD组血清脂联素水平显著低于对照组（P<0.05）。在AD患者的3个亚组中，中度和重度AD组血清脂联素水平显著低于对照组（P<0.05），但轻度AD组与对照组脂联素水平差异不显著（P>0.05）；AD患者3个亚组间血清脂联素水平也存在显著差异（P<0.05）。AD患者血清脂联素水平与MMSE评分呈正相关（r=0.683，P<0.001）。
AD患者血清脂联素水平降低，且与认知障碍程度相关。
