Luo Yan, Liu Meilian
Institute of Metabolism and Endocrinology, Metabolic Syndrome Research Center, the Second Xiangya Hospital, Central South University, Changsha 410011, China Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Institute of Metabolism and Endocrinology, Metabolic Syndrome Research Center, the Second Xiangya Hospital, Central South University, Changsha 410011, China Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
J Mol Cell Biol. 2016 Apr;8(2):120-8. doi: 10.1093/jmcb/mjw012. Epub 2016 Mar 18.
Adiponectin acts as a key regulator of the innate immune system and plays a major role in the progression of inflammation and metabolic disorders. Macrophages and monocytes are representative components of the innate immune system, and their proliferation, plasticity, and polarization are a key component of metabolic adaption. Innate-like lymphocytes such as group 2 innate lymphoid cells (ILC2s), natural killer T (NKT) cells, and gamma delta T (γδ T) cells are also members of the innate immune system and play important roles in the development of obesity and its related diseases. Adiponectin senses metabolic stress and modulates metabolic adaption by targeting the innate immune system under physiological and pathological conditions. Defining the mechanisms underlying the role of adiponectin in regulating innate immunity is crucial to adiponectin-based therapeutic intervention.
脂联素作为固有免疫系统的关键调节因子，在炎症和代谢紊乱的进展中起主要作用。巨噬细胞和单核细胞是固有免疫系统的代表性组成部分，它们的增殖、可塑性和极化是代谢适应的关键组成部分。固有样淋巴细胞，如2型固有淋巴细胞（ILC2s）、自然杀伤T（NKT）细胞和γδT细胞，也是固有免疫系统的成员，在肥胖及其相关疾病的发展中起重要作用。脂联素可感知代谢应激，并在生理和病理条件下通过靶向固有免疫系统来调节代谢适应。明确脂联素在调节固有免疫中作用的潜在机制对于基于脂联素的治疗干预至关重要。
