Ueda-Consolvo Tomoko, Hayashi Atsushi, Ozaki Mayumi, Nakamura Tomoko, Yagou Takaaki, Abe Shinya
Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Jpn J Ophthalmol. 2017 Jul;61(4):347-353. doi: 10.1007/s10384-017-0515-z. Epub 2017 Apr 26.
To assess the correlation between endothelial dysfunction and frequency of antivascular endothelial growth factor (anti-VEGF) treatment for neovascular age-related macular degeneration (nAMD).
We examined 64 consecutive patients with nAMD who were evaluated for endothelial function by use of peripheral arterial tonometry (EndoPAT 2000; Itamar Medical, Caesarea, Israel) at Toyama University Hospital from January 2015. We tallied the number of anti-VEGF treatments between January 2014 and December 2015 and determined the correlation between the number of anti-VEGF injections and endothelial function expressed as the reactive hyperemia index (RHI). Multiple regression analysis was also performed to identify the independent predictors of a larger number of injections.
The mean number of anti-VEGF injections was 8.2 ± 3.3. The mean lnRHI was 0.47 ± 0.17. The lnRHI correlated with the number of anti-VEGF injections (r = -0.56; P = 0.030). The multiple regression analysis revealed that endothelial function, neovascular subtypes, and treatment regimens were associated with the number of injections.
Endothelial dysfunction may affect the efficacy of anti-VEGF therapy. Neovascular subtypes may also predict a larger number of injections.
评估新生血管性年龄相关性黄斑变性（nAMD）患者内皮功能障碍与抗血管内皮生长因子（anti-VEGF）治疗频率之间的相关性。
我们对2015年1月起在富山大学医院连续纳入的64例nAMD患者进行了研究，采用外周动脉张力测量法（EndoPAT 2000；以色列凯撒利亚伊塔玛尔医疗公司）评估其内皮功能。我们统计了2014年1月至2015年12月期间anti-VEGF治疗的次数，并确定了anti-VEGF注射次数与以反应性充血指数（RHI）表示的内皮功能之间的相关性。还进行了多元回归分析以确定注射次数较多的独立预测因素。
anti-VEGF注射的平均次数为8.2±3.3次。平均lnRHI为0.47±0.17。lnRHI与anti-VEGF注射次数相关（r = -0.56；P = 0.030）。多元回归分析显示，内皮功能、新生血管亚型和治疗方案与注射次数有关。
内皮功能障碍可能影响anti-VEGF治疗的疗效。新生血管亚型也可能预示着更多的注射次数。
