Letfullin Renat R, George Thomas F
Department of Physics & Optical Engineering, Rose-Hulman Institute of Technology, 5500 Wabash Ave, Terre Haute, IN 47803, USA.
Office of the Chancellor & Center for Nanoscience, Departments of Chemistry/Biochemistry & Physics/Astronomy, University of Missouri-St. Louis, St. Louis, MO 63121, USA.
Nanomedicine (Lond). 2017 May;12(10):1107-1117. doi: 10.2217/nnm-2017-0053. Epub 2017 Apr 27.
We introduce a new method for selectively destroying cancer cell organelles by electrons emitted from the surface of intracellularly localized nanoparticles exposed to the nonionizing ultraviolet (UV) radiation.
We propose to target cancerous intracellular organelles by nanoparticles and expose them to UV radiation with energy density safe for healthy tissue.
We simulate the number of photoelectrons produced by the nanoparticles made of various metals and radii, calculate their kinetic energy and compare it to the threshold energy for producing biological damage.
Exposure of metal nanoparticles to UV radiation generates photoelectrons with kinetic energies up to 11 eV, which is high enough to produce single- to double-strand breaks in the DNA and damage the cancerous cell organelles.
我们介绍一种新方法，通过暴露于非电离紫外线（UV）辐射的细胞内定位纳米颗粒表面发射的电子来选择性破坏癌细胞细胞器。
我们提议用纳米颗粒靶向癌细胞内的细胞器，并将它们暴露于对健康组织安全的能量密度的紫外线辐射下。
我们模拟了由各种金属和半径制成的纳米颗粒产生的光电子数量，计算了它们的动能，并将其与产生生物损伤的阈值能量进行比较。
金属纳米颗粒暴露于紫外线辐射会产生动能高达11电子伏特的光电子，这足以在DNA中产生单链到双链断裂并破坏癌细胞细胞器。
