Liu Chaochao, Zheng Yi, Sanche Léon
State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou, China.
Département de Médecine Nucléaire et Radiobiologie et Centre de Recherche Clinique, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, QC, Canada.
Photochem Photobiol. 2022 May;98(3):546-563. doi: 10.1111/php.13559. Epub 2021 Nov 25.
The complex physical and chemical interactions between DNA and 0-3 eV electrons released by UV photoionization can lead to the formation of various lesions such as base modifications and cleavage, crosslinks and single strand breaks. Furthermore, in the presence of platinum chemotherapeutic agents, these electrons can cause clustered lesions, including double strand breaks. We explain the mechanisms responsible for these damages via the production 0-3 eV electrons by UVC radiation, and by UV photons of any wavelengths, when they are produced by photoemission from nanoparticles lying within about 10 nm from DNA. We review experimental evidence showing that a single 0-3 eV electron can produce these damages. The foreseen benefits UV-irradiation of nanoparticles targeted to the cell nucleus are mentioned in the context of cancer therapy, as well as the potential hazards to human health when they are present in cells.
DNA与紫外线光电离释放的0-3电子伏特电子之间复杂的物理和化学相互作用，可导致形成各种损伤，如碱基修饰与裂解、交联和单链断裂。此外，在铂类化疗药物存在的情况下，这些电子可导致成簇损伤，包括双链断裂。我们通过UVC辐射产生0-3电子伏特电子以及当纳米颗粒在距DNA约10纳米范围内通过光发射产生任何波长的紫外线光子，来解释造成这些损伤的机制。我们综述了实验证据，表明单个0-3电子伏特电子就能造成这些损伤。在癌症治疗的背景下提到了靶向细胞核的纳米颗粒进行紫外线照射的预期益处，以及它们存在于细胞中时对人类健康的潜在危害。
