Iolascon G, Gimigliano R, Bianco M, De Sire A, Moretti A, Giusti A, Malavolta N, Migliaccio S, Migliore A, Napoli N, Piscitelli P, Resmini G, Tarantino U, Gimigliano F
G. Iolascon, Department of Medical and Surgical Specialties and Dentistry, Second University of Naples, Naples, Italy,
J Nutr Health Aging. 2017;21(5):527-538. doi: 10.1007/s12603-016-0823-x.
The aim of our scoping review was to summarize the state of the art regarding micronutrients in order to identify which of them might effectively improve health status in the areas typically impaired in older people: bone, skeletal muscle, and cognitive function.
Scoping review.
The Italian Study Group on Healthy Aging by Nutraceuticals and Dietary Supplements (HANDS) performed this scoping review, based on the following steps: doing a list of micronutrients related with musculoskeletal or cognitive functions, included in dietary supplements and nutraceuticals commercialized in Italy; planning a research on PubMed, according to an evidence-based approach, in order to the most relevant positive study for each micronutrient into each of the three areas involved (bone, skeletal muscle and cognitive function); identifying the micronutrients effective in maintaining or achieving an adequate health status in older people, specifying the effective and safe daily doses, according to the selected studies.
In literature we found 12 relevant positive studies (1 international society guidelines/recommendations, 1 systematic review, 7 randomized controlled trials, and 3 prospective cohort studies). We showed that only 16 micronutrients resulted to have appropriate scientific evidences in terms of improving musculoskeletal health and/or cognitive function in older people: beta-alanine, calcium, creatine, fluorides, leucine, magnesium, omega-3 fatty acids, potassium, vitamin B6, vitamin B9, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K2, and zinc.
This scoping review showed that selected micronutrients in adequate doses might have an ancillary role in musculoskeletal health and cognitive functions in older people.
我们的范围综述旨在总结有关微量营养素的最新研究状况，以确定其中哪些可能有效改善老年人通常受损的领域的健康状况：骨骼、骨骼肌和认知功能。
范围综述。
意大利营养保健品和膳食补充剂促进健康老龄化研究小组（HANDS）进行了这项范围综述，基于以下步骤：列出与肌肉骨骼或认知功能相关的微量营养素清单，这些微量营养素包含在意大利商业化的膳食补充剂和营养保健品中；根据循证方法在PubMed上进行研究，以便为所涉及的三个领域（骨骼、骨骼肌和认知功能）中的每种微量营养素找到最相关的阳性研究；根据所选研究，确定对维持或实现老年人适当健康状况有效的微量营养素，明确有效且安全的每日剂量。
在文献中我们发现了12项相关的阳性研究（1项国际社会指南/建议、1项系统综述、7项随机对照试验和3项前瞻性队列研究）。我们表明，就改善老年人的肌肉骨骼健康和/或认知功能而言，只有16种微量营养素具有适当的科学证据：β-丙氨酸、钙、肌酸、氟化物、亮氨酸、镁、ω-3脂肪酸、钾、维生素B6、维生素B9、维生素B12、维生素C、维生素D、维生素E、维生素K2和锌。
这项范围综述表明，适当剂量的特定微量营养素可能在老年人的肌肉骨骼健康和认知功能方面发挥辅助作用。
