使用炔丙基碳酸酯进行位点选择性C-H活化和区域特异性环化反应。

Lu Qingquan, Mondal Shobhan, Cembellín Sara, Greßies Steffen, Glorius Frank

Organisch-Chemisches Institut , Westfälische Wilhelms-Universität Münster , Corrensstraße 40 , 48149 Münster , Germany . Email:

Chem Sci. 2019 May 27;10(26):6560-6564. doi: 10.1039/c9sc01703h. eCollection 2019 Jul 14.

Herein we describe an unprecedented Ru-catalyzed site-selective and regiospecific annulation of benzoic acids with propargylic carbonates. The weakly coordinating carboxylic acid moiety outperformed other typically used directing groups in C-H activation, including ketone, nitrile, sulfonamide, amide and strongly coordinating nitrogen heterocycles. This is an important step towards the application of C-H activation reactions in complex (functional) real-world molecules.

在此，我们描述了一种前所未有的钌催化苯甲酸与炔丙基碳酸酯的位点选择性和区域特异性环化反应。在C-H活化中，弱配位的羧酸部分比其他常用的导向基团表现更优，这些导向基团包括酮、腈、磺酰胺、酰胺以及强配位的氮杂环。这是迈向将C-H活化反应应用于复杂（功能性）实际分子的重要一步。