a Department of Experimental Physiology and Pathophysiology, Laboratory of Center for Preclinical Research , Medical University of Warsaw , Warsaw , Poland.
b Laboratory of Physiology and Pathophysiology, Center for Preclinical Research , Medical University of Warsaw , Warsaw , Poland.
Clin Exp Hypertens. 2017;39(3):290-294. doi: 10.1080/10641963.2016.1267191.
The effect of renal denervation on the efficacy of antihypertensive drugs has not yet been elucidated. Twenty-week-old spontaneously hypertensive rats were treated with metoprolol, losartan, indapamide, or saline (controls) and assigned to renal denervation or a sham procedure. Acute hemodynamic measurements were performed ten days later. Series showing a significant interaction between renal denervation and the drugs were repeated with chronic telemetry measurements. In the saline series, denervated rats showed a significantly lower mean arterial blood pressure (blood pressure) than the sham-operated rats. In contrast, in the metoprolol series denervated rats showed a significantly higher blood pressure than sham rats. There were no differences in blood pressure between denervated and sham rats in the losartan and indapamide series. In chronic studies, a 4-week treatment with metoprolol caused a decrease in blood pressure. Renal denervation and sham denervation performed 10 days after the onset of metoprolol treatment did not affect blood pressure. Denervated rats showed markedly reduced renal nerve tyrosine hydroxylase levels. In conclusion, renal denervation decreases blood pressure in hypertensive rats. The hypotensive action of metoprolol, indapamide, and losartan is not augmented by renal denervation, suggesting the absence of synergy between renal denervation and the drugs investigated in this study.
肾去神经术对降压药物疗效的影响尚未阐明。20 周龄自发性高血压大鼠接受美托洛尔、氯沙坦、吲达帕胺或生理盐水（对照）治疗，并分为肾去神经术或假手术组。10 天后进行急性血液动力学测量。与药物呈显著交互作用的系列重复进行慢性遥测测量。在生理盐水系列中，去神经大鼠的平均动脉血压（血压）明显低于假手术大鼠。相比之下，在美托洛尔系列中，去神经大鼠的血压明显高于假大鼠。在氯沙坦和吲达帕胺系列中，去神经和假神经大鼠的血压无差异。在慢性研究中，美托洛尔治疗 4 周导致血压下降。肾去神经术和美托洛尔治疗开始后 10 天进行的假去神经术均不影响血压。去神经大鼠的肾神经酪氨酸羟化酶水平明显降低。结论：肾去神经术可降低高血压大鼠的血压。美托洛尔、吲达帕胺和氯沙坦的降压作用不受肾去神经术增强，提示本研究中研究的药物与肾去神经术之间不存在协同作用。
