波兰中西部地区 HIV 患者和献血者中戊型肝炎病毒 IgG 血清流行率。

Hepatitis E virus IgG seroprevalence in HIV patients and blood donors, west-central Poland.

机构信息

Department of Infectious Diseases, Hepatology and Acquired Immunodeficiencies, Poznan University of Medical Sciences, 3 Szwajcarska Street, 61-285 Poznań, Poland.

Department of Immunology, Chair of Clinical Immunology, Poznan University of Medical Sciences, 5D Rokietnicka Street, 60-806 Poznań, Poland.

出版信息

Int J Infect Dis. 2017 Aug;61:20-22. doi: 10.1016/j.ijid.2017.05.014. Epub 2017 May 30.

DOI:10.1016/j.ijid.2017.05.014

PMID:28576599

Abstract

OBJECTIVE

To assess hepatitis E virus (HEV) seroprevalence in HIV patients and blood donors from one region in Poland.

METHODS

A group of 490 persons (244 HIV patients and 246 blood donors) aged 18-55 years were examined using the anti-HEV IgG assay (Wantai Biological Pharmacy Enterprise, Beijing, China). An analysis of the association between certain factors and the presence of this HEV exposure marker was conducted in both groups.

RESULTS

An HEV seropositivity rate of 50.2% was found. There was no difference in HEV seroprevalence between blood donors (49.6%, 122/246) and HIV patients (50.8%, 124/244) (p=0.569). The anti-HEV IgG positivity rate increased with age as follows: 36.2% (59/163) in persons aged 18-30 years, 52.0% (92/177) in individuals aged 31-40 years and 63.3% (95/150) in those aged 41-55 years. HEV infection occurred in 56.4% (31/55) of people who had never travelled abroad.

CONCLUSIONS

Wielkopolska Region in west-central Poland is an area hyperendemic for HEV infection. In this part of Poland, the exposure of HIV-positive persons to this virus is not greater than that of healthy blood donors.

摘要

目的

评估波兰一个地区的 HIV 患者和献血者中戊型肝炎病毒（HEV）的血清流行率。

方法

使用抗-HEV IgG 检测试剂盒（北京万泰生物药业股份有限公司）对年龄在 18-55 岁的 490 人（244 名 HIV 患者和 246 名献血者）进行了检测。对两组人群中某些因素与该 HEV 暴露标志物存在之间的相关性进行了分析。

结果

发现 HEV 血清阳性率为 50.2%。献血者（49.6%，122/246）和 HIV 患者（50.8%，124/244）之间的 HEV 血清流行率无差异（p=0.569）。抗-HEV IgG 阳性率随年龄增长而增加：年龄在 18-30 岁的人群中为 36.2%（59/163），年龄在 31-40 岁的人群中为 52.0%（92/177），年龄在 41-55 岁的人群中为 63.3%（95/150）。从未出过国的人群中，有 56.4%（31/55）感染了 HEV。