酵母核糖体生物合成的转录调控：一般调控因子的多方面作用。
Transcriptional control of yeast ribosome biogenesis: A multifaceted role for general regulatory factors.
作者信息
Bosio Maria Cristina, Fermi Beatrice, Dieci Giorgio
机构信息
a Department of Chemistry , Life Sciences and Environmental Sustainability, University of Parma , Parma , Italy.
出版信息
Transcription. 2017 Aug 8;8(4):254-260. doi: 10.1080/21541264.2017.1317378. Epub 2017 Apr 27.
Abstract
In Saccharomyces cerevisiae, a group of more than 200 co-regulated genes (Ribi genes) is involved in ribosome biogenesis. This regulon has recently been shown to rely on a small set of transcriptional regulators (mainly Abf1, but also Reb1, Tbf1 and Rap1) previously referred to as general regulatory factors (GRFs) because of their widespread binding and action at many promoters and other specialized genomic regions. Intriguingly, Abf1 binding to Ribi genes is differentially modulated in response to distinct nutrition signaling pathways. Such a dynamic promoter association has the potential to orchestrate both activation and repression of Ribi genes in synergy with neighboring regulatory sites and through the functional interplay of histone acetyltransferases and deacetylases.
摘要
在酿酒酵母中，一组超过200个共同调控的基因（Ribi基因）参与核糖体生物合成。最近发现，这个调控子依赖于一小部分转录调节因子（主要是Abf1，但也包括Reb1、Tbf1和Rap1），这些因子以前被称为一般调节因子（GRFs），因为它们在许多启动子和其他特殊基因组区域广泛结合并发挥作用。有趣的是，Abf1与Ribi基因的结合会根据不同的营养信号通路进行差异调节。这种动态的启动子关联有可能通过与相邻调控位点协同作用，并通过组蛋白乙酰转移酶和去乙酰化酶的功能相互作用，来协调Ribi基因的激活和抑制。
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