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本文引用的文献

1
Abf1 and other general regulatory factors control ribosome biogenesis gene expression in budding yeast.Abf1及其他一般调控因子控制芽殖酵母中的核糖体生物发生基因表达。
Nucleic Acids Res. 2017 May 5;45(8):4493-4506. doi: 10.1093/nar/gkx058.
2
A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis.一种分子滴定系统协调核糖体蛋白基因转录与核糖体 RNA 合成。
Mol Cell. 2016 Nov 17;64(4):720-733. doi: 10.1016/j.molcel.2016.10.003. Epub 2016 Nov 3.
3
A global genetic interaction network maps a wiring diagram of cellular function.一个全球遗传相互作用网络描绘了细胞功能的接线图。
Science. 2016 Sep 23;353(6306). doi: 10.1126/science.aaf1420.
4
Steroid hormone receptors silence genes by a chromatin-targeted mechanism similar to those used for gene activation.类固醇激素受体通过一种类似于用于基因激活的染色质靶向机制使基因沉默。
Transcription. 2017 Jan;8(1):15-20. doi: 10.1080/21541264.2016.1242456. Epub 2016 Oct 4.
5
Role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae.CK2 依赖性磷酸化的 Ifh1 和 Crf1 在酿酒酵母核糖体蛋白基因转录调控中的作用。
Biochim Biophys Acta. 2016 Aug;1859(8):1004-13. doi: 10.1016/j.bbagrm.2016.06.003. Epub 2016 Jun 15.
6
Multiple roles of the general regulatory factor Abf1 in yeast ribosome biogenesis.通用调控因子Abf1在酵母核糖体生物合成中的多种作用
Curr Genet. 2017 Feb;63(1):65-68. doi: 10.1007/s00294-016-0621-3. Epub 2016 Jun 4.
7
Promoter architecture and transcriptional regulation of Abf1-dependent ribosomal protein genes in Saccharomyces cerevisiae.酿酒酵母中Abf1依赖性核糖体蛋白基因的启动子结构与转录调控
Nucleic Acids Res. 2016 Jul 27;44(13):6113-26. doi: 10.1093/nar/gkw194. Epub 2016 Mar 25.
8
Molecular mechanisms of ribosomal protein gene coregulation.核糖体蛋白基因协同调控的分子机制
Genes Dev. 2015 Sep 15;29(18):1942-54. doi: 10.1101/gad.268896.115.
9
Global Promoter Targeting of a Conserved Lysine Deacetylase for Transcriptional Shutoff during Quiescence Entry.一种保守赖氨酸脱乙酰酶的全基因组启动子靶向作用，用于静止期进入时的转录关闭
Mol Cell. 2015 Sep 3;59(5):732-43. doi: 10.1016/j.molcel.2015.07.014. Epub 2015 Aug 20.
10
Eaf1p Is Required for Recruitment of NuA4 in Targeting TFIID to the Promoters of the Ribosomal Protein Genes for Transcriptional Initiation In Vivo.Eaf1p是体内将NuA4募集到核糖体蛋白基因启动子以靶向TFIID进行转录起始所必需的。
Mol Cell Biol. 2015 Sep 1;35(17):2947-64. doi: 10.1128/MCB.01524-14. Epub 2015 Jun 22.

酵母核糖体生物合成的转录调控：一般调控因子的多方面作用。

Transcriptional control of yeast ribosome biogenesis: A multifaceted role for general regulatory factors.

作者信息

Bosio Maria Cristina, Fermi Beatrice, Dieci Giorgio

机构信息

a Department of Chemistry , Life Sciences and Environmental Sustainability, University of Parma , Parma , Italy.

出版信息

Transcription. 2017 Aug 8;8(4):254-260. doi: 10.1080/21541264.2017.1317378. Epub 2017 Apr 27.

DOI:10.1080/21541264.2017.1317378
PMID:28448767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5574525/
Abstract

In Saccharomyces cerevisiae, a group of more than 200 co-regulated genes (Ribi genes) is involved in ribosome biogenesis. This regulon has recently been shown to rely on a small set of transcriptional regulators (mainly Abf1, but also Reb1, Tbf1 and Rap1) previously referred to as general regulatory factors (GRFs) because of their widespread binding and action at many promoters and other specialized genomic regions. Intriguingly, Abf1 binding to Ribi genes is differentially modulated in response to distinct nutrition signaling pathways. Such a dynamic promoter association has the potential to orchestrate both activation and repression of Ribi genes in synergy with neighboring regulatory sites and through the functional interplay of histone acetyltransferases and deacetylases.

摘要

在酿酒酵母中，一组超过200个共同调控的基因（Ribi基因）参与核糖体生物合成。最近发现，这个调控子依赖于一小部分转录调节因子（主要是Abf1，但也包括Reb1、Tbf1和Rap1），这些因子以前被称为一般调节因子（GRFs），因为它们在许多启动子和其他特殊基因组区域广泛结合并发挥作用。有趣的是，Abf1与Ribi基因的结合会根据不同的营养信号通路进行差异调节。这种动态的启动子关联有可能通过与相邻调控位点协同作用，并通过组蛋白乙酰转移酶和去乙酰化酶的功能相互作用，来协调Ribi基因的激活和抑制。