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Venlafaxine-induced galactorrhea.文拉法辛所致溢乳
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文拉法辛所致高催乳素血症性和正常催乳素血症性溢乳的剂量依赖性病程

Dose Dependent Course of Hyperprolactinemic and Normoprolactinemic Galactorrhea Induced by Venlafaxine.

作者信息

Camkurt Mehmet Akif, Gülpamuk Gizem, Fındiklı Ebru, Elve Rengin

机构信息

Department of Psychiatry, Afşin State Hospital, Afşin, Turkey.

Department of Psychiatry, Selçuk University School of Medicine, Selçuk, Turkey.

出版信息

Clin Psychopharmacol Neurosci. 2017 May 31;15(2):181-183. doi: 10.9758/cpn.2017.15.2.181.

DOI:10.9758/cpn.2017.15.2.181
PMID:28449567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5426493/
Abstract

Venlafaxine is a serotonergic and noradrenergic reuptake inhibitor which is used for the treatment of depression. We report a case of galactorrhea in a patient with major depressive disorder after starting treatment with venlafaxine. In particular, we discuss the course of hyper and normoprolactinemic galactorrhea. We managed this side effect initially by dose reduction and further by switching to essitalopram. Physicians should be aware of endocrinologic side effects such as galactorrhea during the serotonin and noradrenaline reuptake inhibitor treatment.

摘要

文拉法辛是一种5-羟色胺能和去甲肾上腺素能再摄取抑制剂，用于治疗抑郁症。我们报告了1例在开始使用文拉法辛治疗后发生溢乳的重度抑郁症患者。特别是，我们讨论了高泌乳素血症性溢乳和正常泌乳素血症性溢乳的病程。我们最初通过减少剂量、进而改用艾司西酞普兰来处理这一副作用。医生在5-羟色胺和去甲肾上腺素再摄取抑制剂治疗期间应注意内分泌副作用，如溢乳。