与艾司西酞普兰相关的溢乳病例。
A case of galactorrhea associated with excitalopram.
机构信息
Department of Psychiatry, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea.
出版信息
Psychiatry Investig. 2009 Sep;6(3):230-2. doi: 10.4306/pi.2009.6.3.230. Epub 2009 Jul 15.
Abstract
Escitalopram is one of the most popular selective serotonin reuptake inhibitors (SSRIs) in current use as a first-line treatment for depression. Escitalopram is well-tolerated and rarely associated with serious side effects. Endocrine and reproductive side effects of serotonergic antidepressants are uncommon and galactorrhea is very rarely mentioned among SSRI-related side effects. Serotonin-enhancing antidepressants may result in a rise in prolactin levels through suppression of dopamine neurotransmission. In the present study, we report a case of hyperprolactinemic galactorrhea associated with escitalopram. A 36-year-old woman developed galactorrhea after initiation of escitalopram for depression and was found to have an elevated prolactin level. Escitalopram was discontinued with resolution of the patient's galactorrhea and normalization of her prolactin level.
摘要
依他普仑是目前作为抑郁症一线治疗药物最常用的选择性 5-羟色胺再摄取抑制剂（SSRIs）之一。依他普仑具有良好的耐受性，很少引起严重的副作用。SSRIs 相关的内分泌和生殖系统副作用并不常见，而泌乳则很少被提及。增强 5-羟色胺的抗抑郁药可能通过抑制多巴胺神经传递而导致催乳素水平升高。在本研究中，我们报告了一例与依他普仑相关的高催乳素血症性泌乳。一名 36 岁女性在因抑郁症开始使用依他普仑后出现泌乳，并发现催乳素水平升高。停用依他普仑后，患者的泌乳停止，催乳素水平恢复正常。
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本文引用的文献
1
A case with euprolactinemic galactorrhea induced by escitalopram.一例由艾司西酞普兰引起的催乳素正常性溢乳症病例。
Int J Psychiatry Med. 2007;37(3):275-8. doi: 10.2190/PM.37.3.d.
2
"Dopamine-dependent" side effects of selective serotonin reuptake inhibitors: a clinical review.选择性5-羟色胺再摄取抑制剂的“多巴胺依赖型”副作用：一项临床综述
J Clin Psychiatry. 2004 Aug;65(8):1064-8. doi: 10.4088/jcp.v65n0806.
3
Antipsychotic-induced hyperprolactinaemia in women: pathophysiology, severity and consequences. Selective literature review.女性抗精神病药物所致高催乳素血症：病理生理学、严重程度及后果。选择性文献综述
Br J Psychiatry. 2003 Mar;182:199-204. doi: 10.1192/bjp.182.3.199.
4
Reversible galactorrhea and prolactin elevation related to fluoxetine use.与使用氟西汀相关的可逆性溢乳和催乳素升高。
Mayo Clin Proc. 2001 Feb;76(2):215-6. doi: 10.1016/S0025-6196(11)63132-7.
5
Oestrogen, progesterone and serotonin converge on GABAergic neurones in the monkey hypothalamus.
J Neuroendocrinol. 2001 Feb;13(2):182-92. doi: 10.1046/j.1365-2826.2001.00612.x.
6
Psychoneuroendocrinology of depression. Prolactin.抑郁症的心理神经内分泌学。催乳素。
Psychiatr Clin North Am. 1998 Jun;21(2):341-58. doi: 10.1016/s0193-953x(05)70009-5.
7
The effect of fluvoxamine on serum prolactin and serum sodium concentrations: relation to platelet 5-HT2A receptor status.氟伏沙明对血清催乳素和血清钠浓度的影响：与血小板5-HT2A受体状态的关系。
J Clin Psychopharmacol. 1997 Aug;17(4):292-7. doi: 10.1097/00004714-199708000-00009.
8
Neuroendocrine effects of a 20-mg citalopram infusion in healthy males. A placebo-controlled evaluation of citalopram as 5-HT function probe.20毫克西酞普兰静脉输注对健康男性的神经内分泌影响。以西酞普兰作为5-羟色胺功能探针的安慰剂对照评估。
Neuropsychopharmacology. 1996 Apr;14(4):253-63. doi: 10.1016/0893-133X(95)00117-V.
9
Breast tenderness and enlargement induced by sertraline.
Am J Psychiatry. 1994 Sep;151(9):1395-6. doi: 10.1176/ajp.151.9.1395b.
10
Extrapyramidal symptoms with selective serotonin reuptake inhibitors.选择性5-羟色胺再摄取抑制剂引起的锥体外系症状
Br J Psychiatry. 1994 Dec;165(6):728-33. doi: 10.1192/bjp.165.6.728.
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