与艾司西酞普兰相关的溢乳病例。
A case of galactorrhea associated with excitalopram.
机构信息
Department of Psychiatry, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea.
出版信息
Psychiatry Investig. 2009 Sep;6(3):230-2. doi: 10.4306/pi.2009.6.3.230. Epub 2009 Jul 15.
Escitalopram is one of the most popular selective serotonin reuptake inhibitors (SSRIs) in current use as a first-line treatment for depression. Escitalopram is well-tolerated and rarely associated with serious side effects. Endocrine and reproductive side effects of serotonergic antidepressants are uncommon and galactorrhea is very rarely mentioned among SSRI-related side effects. Serotonin-enhancing antidepressants may result in a rise in prolactin levels through suppression of dopamine neurotransmission. In the present study, we report a case of hyperprolactinemic galactorrhea associated with escitalopram. A 36-year-old woman developed galactorrhea after initiation of escitalopram for depression and was found to have an elevated prolactin level. Escitalopram was discontinued with resolution of the patient's galactorrhea and normalization of her prolactin level.
依他普仑是目前作为抑郁症一线治疗药物最常用的选择性 5-羟色胺再摄取抑制剂（SSRIs）之一。依他普仑具有良好的耐受性，很少引起严重的副作用。SSRIs 相关的内分泌和生殖系统副作用并不常见，而泌乳则很少被提及。增强 5-羟色胺的抗抑郁药可能通过抑制多巴胺神经传递而导致催乳素水平升高。在本研究中，我们报告了一例与依他普仑相关的高催乳素血症性泌乳。一名 36 岁女性在因抑郁症开始使用依他普仑后出现泌乳，并发现催乳素水平升高。停用依他普仑后，患者的泌乳停止，催乳素水平恢复正常。
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