Ness Kirsten K, Howell Carrie R, Bjornard Kari L
Expert Rev Qual Life Cancer Care. 2017;2(2):79-85. doi: 10.1080/23809000.2017.1300507. Epub 2017 Mar 6.
Adult survivors of childhood cancer are at risk for frailty, a state of diminished physiologic reserve, typically seen in older adults, associated with morbidity and mortality. They are also at risk for poor quality of life. This review explores potential associations between frailty and quality of life and proposes potential interventions that may prevent or remediate frail health.
A literature search using MEDLINE and EMBASE was undertaken using key words: childhood cancer survivors and each of the following: frailty, physical performance, emotional health, and quality of life. 796 abstracts were reviewed for relevance. Reference lists for retrieved articles were consulted for pertinent manuscripts (N=40). Recent literature (from January 2013 to November 2016) was obtained using the key words: aging and frailty and quality of life. The final reference list includes 44 documents.
Childhood cancer survivors are at risk for frailty and less than optimal quality of life. Poor emotional health may contribute to this association. Further research is needed to better explain these associations and to provide a foundation for the development of interventions designed to prevent and remediate frail health and suboptimal quality of life in this population.
儿童癌症成年幸存者面临虚弱风险，这是一种生理储备下降的状态，通常见于老年人，与发病率和死亡率相关。他们还面临生活质量差的风险。本综述探讨了虚弱与生活质量之间的潜在关联，并提出了可能预防或改善虚弱健康状况的潜在干预措施。
使用关键词“儿童癌症幸存者”以及以下各项：虚弱、身体机能、情绪健康和生活质量，在MEDLINE和EMBASE数据库中进行了文献检索。共筛选了796篇摘要以确定其相关性。查阅了检索到文章的参考文献列表以获取相关手稿（N = 40）。使用关键词“衰老、虚弱和生活质量”获取了近期文献（2013年1月至2016年11月）。最终参考文献列表包括44篇文献。
儿童癌症幸存者面临虚弱风险且生活质量欠佳。情绪健康不佳可能导致了这种关联。需要进一步研究以更好地解释这些关联，并为制定旨在预防和改善该人群虚弱健康状况及欠佳生活质量的干预措施奠定基础。
