癌症和癌症治疗会加速衰老吗？
Do Cancer and Cancer Treatments Accelerate Aging?
机构信息
Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Division of Hematology, Oncology and Transplantation, University of Minnesota, 425 E River Pkwy, Minneapolis, MN, 55455, USA.
出版信息
Curr Oncol Rep. 2022 Nov;24(11):1401-1412. doi: 10.1007/s11912-022-01311-2. Epub 2022 Jul 7.
PURPOSE OF REVIEW
This review focuses on describing the mechanisms and clinical manifestations that underlie accelerated aging associated with cancer and its treatment.
RECENT FINDINGS
The direct and indirect effects of cancer and its treatment are associated with late occurrence of comorbidities that happen earlier or more frequently in cancer survivors compared to cancer-free individuals, otherwise known as accelerated aging. Use of senolytics and dietary and exercise interventions including prehabilitation, caloric restriction, and rehabilitation are currently under investigation to reverse or decelerate the aging process and will be covered in this review. Further research on how to decelerate or reverse aging changes associated with cancer and its treatment will be of paramount importance as the number of cancer survivors continues to grow.
目的综述
本综述重点描述了与癌症及其治疗相关的加速衰老的潜在机制和临床表现。
最近的发现
癌症及其治疗的直接和间接影响与癌症幸存者比无癌症个体更早或更频繁发生的合并症有关，这被称为加速衰老。 使用衰老细胞清除剂以及包括预康复、热量限制和康复在内的饮食和运动干预措施正在进行研究，以逆转或减缓衰老过程，这将在本综述中介绍。 随着癌症幸存者人数的不断增加，进一步研究如何减缓或逆转与癌症及其治疗相关的衰老变化将至关重要。
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