Vos Stephanie J B, van Boxtel Martin P J, Schiepers Olga J G, Deckers Kay, de Vugt Marjolein, Carrière Isabelle, Dartigues Jean-François, Peres Karine, Artero Sylvaine, Ritchie Karen, Galluzzo Lucia, Scafato Emanuele, Frisoni Giovanni B, Huisman Martijn, Comijs Hannie C, Sacuiu Simona F, Skoog Ingmar, Irving Kate, O'Donnell Catherine A, Verhey Frans R J, Visser Pieter Jelle, Köhler Sebastian
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
Inserm, U1061, Montpellier, France.
J Alzheimers Dis. 2017;58(2):537-547. doi: 10.3233/JAD-161208.
Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual's prevention potential for dementia.
We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old.
9,387 non-demented individuals were recruited from the European population-based DESCRIPA study. An individual's LIBRA index was calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1-16).
In midlife (55-69 y, n = 3,256) and late life (70-79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80-97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia.
LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.
最近，脑健康生活方式（LIBRA）指数被开发出来，用于评估个体预防痴呆症的潜力。
我们研究了LIBRA指数对中年、老年和高龄老年人新发痴呆症的预测效度。
从基于欧洲人群的DESCRIPT A研究中招募了9387名无痴呆症个体。个体的LIBRA指数仅基于可改变的风险因素计算得出：抑郁、糖尿病、身体活动、高血压、肥胖、吸烟、高胆固醇血症、冠心病以及轻度/中度饮酒。采用Cox回归检验LIBRA对随访期痴呆症的预测效度（平均7.2年，范围1 - 16年）。
在中年（55 - 69岁，n = 3256）和老年（70 - 79岁，n = 4320）人群中，痴呆症风险随LIBRA得分升高而增加。中风险和高风险组个体患痴呆症的风险高于低风险组。在高龄老年人（80 - 97岁，n = 1811）中，较高的LIBRA得分并未增加痴呆症风险。
LIBRA可能是一种有用的工具，可用于识别中年及可能老年人群中需要进行痴呆症一级预防干预的个体，但不适用于高龄老年人。
