Jandackova Vera K, Koenig Julian, Jarczok Marc N, Fischer Joachim E, Thayer Julian F
Department of Internal Medicine, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
Department of Human Movement Studies, Human Motion Diagnostic Centre, University of Ostrava, Ostrava, Czech Republic.
PLoS One. 2017 Apr 28;12(4):e0176014. doi: 10.1371/journal.pone.0176014. eCollection 2017.
Type-D personality, defined as a combination of high negative affect and high social isolation, has been associated with poor health outcomes. However, pathways underlying this association are largely unknown. We investigated the relationship between Type-D personality and several biological and behavioral pathways including the autonomic nervous system, the immune system, glucose regulation and sleep in a large, apparently healthy sample.
Data from a total of 646 respondents (age 41.6±11.5, 12,2% women) were available for analysis. Persons with Type-D (negative affect and social isolation score ≥10) were contrasted with those without Type-D. Measures of plasma fibrinogen levels, white blood cell count, high sensitivity C-reactive protein, fasting plasma glucose (FPG), cholesterol, high-density and low-density lipoprotein, glycated hemoglobin (HbA1c), creatinine, triglycerides, and albumin were derived from fasting blood samples. Urine norepinephrine and free cortisol were determined by high-performance liquid chromatography. Time-domain heart rate variability (HRV) measures were calculated for the 24hr recording period and for nighttime separately.
Persons with Type-D had higher HbA1c, FPG, and fibrinogen, and lower nighttime HRV than those without Type-D, suggesting worse glycemic control, systemic inflammation and poorer autonomic nervous system modulation in Type-D persons. In addition, those with Type-D reported less social support and greater sleep difficulties while no group differences were observed for alcohol and cigarette consumption, physical activity and body mass index.
Findings provide some of the first evidence for multiple possible biological and behavioral pathways between Type-D personality and increased morbidity and mortality.
D型人格被定义为高消极情绪和高社交孤立的结合，与不良健康结果相关。然而，这种关联背后的途径在很大程度上尚不清楚。我们在一个看似健康的大样本中研究了D型人格与几种生物和行为途径之间的关系，这些途径包括自主神经系统、免疫系统、血糖调节和睡眠。
共有646名受访者（年龄41.6±11.5岁，12.2%为女性）的数据可供分析。将D型人格者（消极情绪和社交孤立得分≥10）与非D型人格者进行对比。血浆纤维蛋白原水平、白细胞计数、高敏C反应蛋白、空腹血糖（FPG）、胆固醇、高密度和低密度脂蛋白、糖化血红蛋白（HbA1c）、肌酐、甘油三酯和白蛋白的测量值来自空腹血样。尿去甲肾上腺素和游离皮质醇通过高效液相色谱法测定。分别计算24小时记录期和夜间的时域心率变异性（HRV）测量值。
与非D型人格者相比，D型人格者的HbA1c、FPG和纤维蛋白原水平更高，夜间HRV更低，这表明D型人格者的血糖控制更差、全身炎症更严重且自主神经系统调节更差。此外，D型人格者报告的社会支持较少，睡眠困难较多，而在饮酒、吸烟、身体活动和体重指数方面未观察到组间差异。
研究结果为D型人格与发病率和死亡率增加之间多种可能的生物和行为途径提供了一些初步证据。
