铜绿假单胞菌中的密码子使用情况。
Codon usage in Pseudomonas aeruginosa.
作者信息
West S E, Iglewski B H
机构信息
Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, NY 14642.
出版信息
Nucleic Acids Res. 1988 Oct 11;16(19):9323-35. doi: 10.1093/nar/16.19.9323.
Abstract
We have generated a codon usage table for Pseudomonas aeruginosa. Codon usage in P. aeruginosa is extremely biased. In contrast to E. coli and yeast, P. aeruginosa preferentially uses those codons within a synonymous codon group with the strongest predicted codon-anticodon interaction. We were unable to correlate a particular codon usage pattern with predicted levels of mRNA expressivity. The choice of a third base reflects the high guanine plus cytosine content of the P. aeruginosa genome (67.2%) and cytosine is the preferred nucleotide for the third codon position.
摘要
我们已经生成了铜绿假单胞菌的密码子使用表。铜绿假单胞菌的密码子使用存在极大的偏向性。与大肠杆菌和酵母不同，铜绿假单胞菌优先使用同义密码子组中预测的密码子 - 反密码子相互作用最强的那些密码子。我们无法将特定的密码子使用模式与预测的mRNA表达水平相关联。第三个碱基的选择反映了铜绿假单胞菌基因组中鸟嘌呤加胞嘧啶的高含量（67.2%），并且胞嘧啶是第三个密码子位置的首选核苷酸。
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