INSERM, UMR1163, Laboratory of Intestinal Immunity, France.
INSERM, UMR1163, Laboratory of Intestinal Immunity, France; INRA Micalis UMR1319, 78350 Jouy-en-Josas, France; Université Paris Descartes-Sorbonne Paris Cité and Institut Imagine, 75015 Paris, France.
Curr Opin Microbiol. 2017 Feb;35:100-109. doi: 10.1016/j.mib.2017.03.004. Epub 2017 Apr 25.
The Th17 cell composition in the murine gut is strikingly dependent on the presence of the commensal segmented filamentous bacteria (SFB). SFB potently stimulates innate and adaptive immune responses and protects the host from pathogens both in and outside of the gut, partly due to its unique ability to promote a Th17-fostering environment. Recent work has highlighted the role of the tight adherence of SFB to the intestinal surface in mediating the potent immunostimulatory potential of SFB. Progress has also been made in our understanding of how SFB fosters this protective immune environment on the cellular and molecular level. This review focuses on the ability of SFB to specifically stimulate Th17 immunity.
肠道中 Th17 细胞的组成明显依赖于共生的梭状芽胞杆菌（SFB）的存在。SFB 强烈刺激先天和适应性免疫反应，并保护宿主免受肠道内外病原体的侵害，部分原因是其促进 Th17 细胞生长环境的独特能力。最近的研究强调了 SFB 紧密粘附在肠道表面在介导 SFB 强大的免疫刺激潜能中的作用。我们在理解 SFB 如何在细胞和分子水平上促进这种保护性免疫环境方面也取得了进展。这篇综述重点介绍了 SFB 特异性刺激 Th17 免疫的能力。
