Ditzel Ricky M, Chiu Lucinda T, Siblini Hiba, Cannon Hershel W, Goel Keshav, Pearce John J, Byrne Nika, Bhabad Sudeep, Marshall Michael S, Byrne Richard W
Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois.
Department of Pathology, Rush University Medical Center, Chicago, Illinois.
J Neurosurg Case Lessons. 2025 Mar 10;9(10). doi: 10.3171/CASE24670.
Tumor-to-tumor metastasis (TTM) is an exceptionally rare phenomenon. To date, only 12 cases of the metastasis of clear cell renal cell carcinoma (ccRCC) to a meningioma have been reported in the literature. The authors present a unique case of TTM involving ccRCC metastasizing to a meningioma in a patient with a history of both primary cancers.
A 58-year-old male with a history of 2 primary cancers developed a biphasic tumor diagnosed as TTM of ccRCC to meningioma. The patient initially presented with left lower-extremity (LLE) weakness and underwent subtotal resection of his meningioma. Postsurgical imaging revealed rapid tumor progression, for which the patient completed adjuvant radiotherapy. Concurrently, the patient developed hematuria and was diagnosed with ccRCC. Subsequent recurrent LLE weakness and intracranial tumor progression prompted re-resection, revealing a TTM.
In patients with a history of multiple cancers who present with recurrent intracranial disease progression radiographically and/or clinically, it is worth considering TTM in the differential diagnosis to facilitate multidisciplinary workup, management, and treatment. https://thejns.org/doi/10.3171/CASE24670.
肿瘤-to-肿瘤转移（TTM）是一种极为罕见的现象。迄今为止，文献中仅报道了12例透明细胞肾细胞癌（ccRCC）转移至脑膜瘤的病例。作者报告了一例独特的TTM病例，一名有两种原发性癌症病史的患者，ccRCC转移至脑膜瘤。
一名有两种原发性癌症病史的58岁男性发生了一例双相性肿瘤，诊断为ccRCC转移至脑膜瘤。患者最初表现为左下肢（LLE）无力，接受了脑膜瘤次全切除术。术后影像学检查显示肿瘤迅速进展，患者为此完成了辅助放疗。同时，患者出现血尿，被诊断为ccRCC。随后复发的LLE无力和颅内肿瘤进展促使再次手术切除，发现为TTM。
对于有多种癌症病史且出现影像学和/或临床复发性颅内疾病进展的患者，在鉴别诊断中值得考虑TTM，以便于进行多学科检查、管理和治疗。https://thejns.org/doi/10.3171/CASE24670
