Departamento de Química Física I, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
Departamento de Química Física I, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
Adv Colloid Interface Sci. 2017 Nov;249:290-307. doi: 10.1016/j.cis.2017.04.009. Epub 2017 Apr 20.
Soft assemblies obtained following the Layer-by-Layer (LbL) approach are accounted among the most interesting systems for designing biomaterials and drug delivery platforms. This is due to the extraordinary versatility and flexibility offered by the LbL method, allowing for the fabrication of supramolecular multifunctional materials using a wide range of building blocks through different types of interactions (electrostatic, hydrogen bonds, acid-base or coordination interactions, or even covalent bonds). This provides the bases for the building of materials with different sizes, shapes, compositions and morphologies, gathering important possibilities for tuning and controlling the physico-chemical properties of the assembled materials with precision in the nanometer scale, and consequently creating important perspective for the application of these multifunctional materials as cargo systems in many areas of technological interest. This review studies different physico - chemical aspects associated with the assembly of supramolecular materials by the LbL method, paying special attention to the description of these aspects playing a central role in the application of these materials as cargo platforms for encapsulation and release of active compounds.
通过层层自组装（LbL）方法获得的软组装体被认为是设计生物材料和药物输送平台最有趣的系统之一。这是由于 LbL 方法提供了非凡的多功能性和灵活性，允许使用各种构建块通过不同类型的相互作用（静电、氢键、酸碱或配位相互作用，甚至共价键）来制造超分子多功能材料。这为具有不同尺寸、形状、组成和形态的材料的构建提供了基础，为精确调节和控制组装材料的物理化学性质提供了重要的可能性，纳米尺度，并因此为这些多功能材料作为许多技术领域中货物系统的应用创造了重要的前景。本综述研究了通过 LbL 方法组装超分子材料相关的不同物理化学方面，特别关注在这些材料作为封装和释放活性化合物的货物平台的应用中起核心作用的这些方面的描述。
