HIV-1 对 I 型干扰素反应的抑制：HIV 清除的潜在靶点。
Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication.
机构信息
Ottawa Hospital Research Institute, ORCC Room C4445, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Ottawa Hospital Research Institute, ORCC Room C4445, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada; Division of Infectious Diseases, Ottawa Hospital-General Campus, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.
出版信息
Cytokine Growth Factor Rev. 2017 Oct;37:1-16. doi: 10.1016/j.cytogfr.2017.04.004. Epub 2017 Apr 24.
By interfering with the type I interferon (IFN1) response, human immunodeficiency virus 1 (HIV-1) can circumvent host antiviral signalling and establish persistent viral reservoirs. HIV-1-mediated defects in the IFN pathway are numerous, and include the impairment of protein receptors involved in pathogen detection, downstream signalling cascades required for IFN1 upregulation, and expression or function of key IFN1-inducible, antiviral proteins. Despite this, the activation of IFN1-inducible, antiviral proteins has been shown to facilitate the killing of latently HIV-infected cells in vitro. Understanding how IFN1 signalling is blocked in physiologically-relevant models of HIV-1 infection, and whether these defects can be reversed, is therefore of great importance for the development of novel therapeutic strategies aimed at eradicating the HIV-1 reservoir.
通过干扰 I 型干扰素（IFN1）反应，人类免疫缺陷病毒 1（HIV-1）可以规避宿主抗病毒信号转导并建立持续的病毒储存库。HIV-1 介导的 IFN 途径缺陷很多，包括参与病原体检测的蛋白受体受损、上调 IFN1 所需的下游信号级联反应受损，以及关键的 IFN1 诱导、抗病毒蛋白的表达或功能受损。尽管如此，IFN1 诱导的抗病毒蛋白的激活已被证明可促进体外潜伏 HIV 感染细胞的杀伤。因此，了解 HIV-1 感染的生理相关模型中 IFN1 信号转导如何被阻断，以及这些缺陷是否可以逆转，对于开发旨在消除 HIV-1 储存库的新型治疗策略非常重要。
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