Magistro G, Marcon J, Schubert S, Gratzke C, Stief C G
Urologische Klinik und Poliklinik der Universität München, Campus Großhadern, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, München, Deutschland.
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität München, München, Deutschland.
Urologe A. 2017 Jun;56(6):720-727. doi: 10.1007/s00120-017-0391-7.
Urinary tract infections are among the most common bacterial infections worldwide. The management has become a public health concern of socioeconomic importance. Every second woman will experience at least one episode in her lifetime. Due to the emergence of multiresistant pathogens and the developmental void, treatment has become more challenging over the years. Deciphering the complex molecular interaction between host and pathogen is necessary to identify potent treatment targets for future approaches. The objective of this review is to present novel aspects on the pathogenesis of urinary tract infections and its relevance for clinical practice.
尿路感染是全球最常见的细菌感染之一。其管理已成为具有社会经济重要性的公共卫生问题。每两名女性中就有一人在一生中至少会经历一次尿路感染。由于多重耐药病原体的出现以及研发空白，多年来治疗变得更具挑战性。破解宿主与病原体之间复杂的分子相互作用对于确定未来治疗方法的有效靶点至关重要。本综述的目的是介绍尿路感染发病机制的新方面及其与临床实践的相关性。
